Mice missing a copy of the gene ASH1L have excess synapses and autism-like behavioral differences, some of which are reversed by boosting an ASH1L-regulated gene.
Spectrum: Autism Research News
Tag: mouse models
Girls and young women with Rett syndrome have less severe anxiety and breathing problems after treatment with trofinetide, an analogue of insulin-like growth factor 1, according to an unpublished placebo-controlled trial.
Excitatory and inhibitory neurons can derive from the same cellular source in the developing human brain, a new study suggests, overturning a 20-year-old hypothesis. Tomasz Nowakowski discusses the finding’s implications for autism research.
Infection during pregnancy can tweak a mouse’s gut microbiome in ways that have lasting effects on her pups’ immune system and increase their chances of gut inflammation, a new study suggests.
A new viral variant can deliver genes exclusively to the brain, overcoming a key hurdle in treating neurological conditions using gene therapy.
In mice with a mutated copy of SHANK3, stress induces social deficits and alters gene expression in certain excitatory neurons. But eliminating a stress-related protein that regulates SHANK3 restores typical social functioning in the animals.
New software can automatically identify and quantify mouse social behavior from videos, saving researchers time.
Deleting a copy of the gene TBX1 depletes the fatty myelin insulation that surrounds neurons and reduces cognitive speed in mice.
A potential new gene therapy delivered via a single injection mimics ratios of proteins normally found in cells.