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Spectrum: Autism Research News

Tag: mouse models

August 2021
Micrograph showing missing sodium ion channels in cerebral cortex of mice with two mutated copies of SCN2A gene.

Model mice hint at sodium channel gene’s contribution to autism

by  /  27 August 2021

Altered electrical activity in the neurons of mice with a mutated copy of SCN2A may explain the animals’ autism-like social behaviors.

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Illustration of brain showing overexcited and underexcited parts of the brain represented by jagged and loose squiggles.

Disruptions to brain’s ‘thermostat’ may underpin autism traits

by  /  18 August 2021

Mounting evidence suggests that autism often involves upsets in homeostatic plasticity, a set of processes neurons use to stabilize their activity. These disruptions result from a range of autism-linked mutations and may help to explain the condition’s famed heterogeneity.

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Drugs boost serotonin, socialization in multiple autism mouse models

by  /  6 August 2021

The finding that MDMA and an experimental serotonin agonist increase sociability across six different model mice suggests that disparate autism-linked mutations converge on the same underlying pathways.

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Images shows a pyramidal neuron.

How mutations in top autism gene could lead to seizures

by  /  5 August 2021

Deleterious mutations in an autism-associated gene can make neurons hyperexcitable, raising the risk of epileptic seizures.

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July 2021
Micrographs comparing motor cortex neurons in mice with and without an extra copy of MECP2 gene.

Blocking key pathway reverses brain, behavior changes in autism mouse model

by  /  19 July 2021

Neurons in mice with an autism-linked mutation sprout extraneous protrusions, an overgrowth accompanied by above-average motor learning. Inhibiting a cell signaling pathway reverses the effect.

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Four brown lab mice in a cage, top-down view, with one mouse away from the group.

Autism-linked mutation may blur brain’s boundary between self, others

by  /  15 July 2021

A mutation in the autism-linked gene SHANK3 changes how neurons encode information about social agency in mice.

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Micrograph showing fewer neurons in fetal mice whose mothers have only one functional copy of PTEN.

Maternal genetics may contribute to autism-like traits in mice via inflammation

by  /  2 July 2021

A mouse model hints that genes linked to inflammation in some women may increase the likelihood of autism in their children.

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June 2021
Dr. Huda Zoghbi portrait

Huda Zoghbi: Taking genetic inquiry to the next level

by  /  25 June 2021

Over the course of a career spanning more than three decades, Huda Zoghbi has won almost every major biology and neuroscience research award that exists. More than 20 years since she discovered the gene behind Rett syndrome, she remains laser focused on unlocking the condition’s secrets and finding effective treatments.

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Mouse brain cells seen in red

Autism-linked mutation may disrupt brain cell migration

by  /  23 June 2021

Mutations in CUL3, a leading autism gene, may disrupt the movements of neurons during development; correcting this misdirection could lead to an autism therapy.

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Micrographs of mouse astrocytes with high levels of inflammatory molecules.

Immune-regulating cells contribute to autism-like traits in mice

by  /  21 June 2021

The link between autism and prenatal exposure to an immune response may involve altered levels of immune cells, according to a new study.

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