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Spectrum: Autism Research News

Tag: mouse models

July 2022
Ann Kennedy stands against the wall of a brightly lit hallway wearing a black and red dress.

Rising star: Ann Kennedy bridges gap between biology, computational theory

by  /  26 July 2022

A theoretical neuroscientist, Kennedy uses a blend of computational modeling and real-world experiments to understand how brain activity shapes the behaviors of animals that model autism and other conditions.

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Plethora of protein-making machines in neurons may underlie fragile X

by  /  21 July 2022

An overabundance of ribosomes drives an imbalance of proteins produced from long and short genetic transcripts in a mouse model of fragile X syndrome.

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Illustration shows calcium signaling astrocytes, which are star-shaped and change color from light blue to purple.

Portrait of a research field: astrocytes in autism

by  /  14 July 2022

Long cast in supporting roles in the brain, astrocytes are now emerging as primary players in certain characteristics of autism and related conditions.

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Mouse study links dopamine in cerebellum to social behavior

by  /  6 July 2022

The signaling molecule’s social role in the ‘little brain’ involves Purkinje neurons in the Crus I and Crus II regions, a new study reveals.

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June 2022

Poor sleep shifts social circuit in mice

by  /  20 June 2022

Even temporary bouts of too little non-REM sleep can lead to long-term changes in how the animals respond to certain social situations, new research suggests.

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Mice without DDX3X are slow to grow neurons

by  /  17 June 2022

The gene helps neurons exit the cell-maturation cycle during fetal brain development, a new study shows. But male and female mice respond differently to DDX3X loss.

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Gene therapy targets interneurons to tackle Dravet syndrome

by  /  13 June 2022

The approach, tested in mice, selectively boosts the expression of the autism-linked gene SCN1A in a subgroup of inhibitory cells.

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Two top autism-linked proteins connect to build cell ‘skeleton’

by  /  9 June 2022

ADNP and SHANK3 proteins may bind together and alter a neuron’s internal scaffold, hinting at a mechanism that, when disrupted, may underlie several forms of autism.

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May 2022
Ultrasound in black and white shows a pattern.

Heart anomalies abound in mouse models of autism

by  /  23 May 2022

Of nine genetic models examined in a new study, all had some incidence of cardiac abnormalities. But the problems varied widely depending on the affected genes.

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White lab mice bunched up in corner of cage.

Mouse models mirror cerebellum patterns seen in autism

by  /  12 May 2022

Animals with different autism-linked mutations share disruptions to the mTOR signaling pathway, pointing to a potential molecular mechanism for the atypical cerebellar development seen in some autistic people.

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