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Spectrum: Autism Research News

Tag: mouse models

December 2020
White lab mouse sitting in a gloved hand.

Notable papers in autism research, 2020

by  /  23 December 2020

Gene therapies and the factors influencing autism traits top Spectrum’s list of the 10 most notable research findings we covered in 2020.

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Protein in brain

Drug helps mice with autism-linked mutation recognize others

by  /  21 December 2020

Mice that model 22q11.2 deletion syndrome lack social memory, but that trait can be reversed using a drug that targets the flow of potassium ions in neurons.

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Oxytocin neurons stained pink and green.

Autism-linked gene exerts varied effects on oxytocin circuits in mice

by  /  18 December 2020

Two types of neurons process social information, a new mouse study suggests, but only one is disrupted in mice missing the autism-linked gene FMR1.

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November 2020
SYNGAP1 protein between neurons.

Reactions from the 2020 SYNGAP1 Scientific Conference

by  /  25 November 2020

Spectrum is covering the 2020 International SYNGAP1 Scientific Conference, which took place virtually because of the coronavirus pandemic. Here we’re highlighting researchers’ reactions to noteworthy presentations.

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Dilated mouse pupil

Mice reveal roots of sensory issues tied to top autism gene

by  /  23 November 2020

Mice with mutations in the autism-linked gene SYNGAP1 have trouble sensing touch, which may stem in part from brain-circuit alterations and dulled alertness.

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Micrograph of nerve cells being targeted by CRISPR enzyme to activate the silenced gene in Angelman syndrome

Prenatal CRISPR therapy blocks Angelman syndrome traits in mice

by  /  9 November 2020

A gene-editing treatment shows long-lasting effects in a mouse model of Angelman syndrome, a genetic condition related to autism.

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Fifteen different drugs commonly prescribed to people with autism created unique behavioral signatures in mice.

‘MoSeq’ identifies drug-specific behaviors in autism mouse model

by  /  2 November 2020

A tool that relies on video cameras and machine learning can identify mice that have mutations in a top autism gene by their behaviors. It also detects how a widely used autism drug affects their movements.

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October 2020
White mouse grooming.

Nighttime light affects sleep, repetitive behaviors in autism mouse model

by  /  5 October 2020

Mice missing an autism gene groom themselves more than usual and have altered circadian rhythms after nighttime exposure to light.

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September 2020
White lab mouse sitting in a gloved hand.

Silencing ‘poison exon’ eliminates deadly seizures in mice

by  /  24 September 2020

A new treatment curbs deadly seizures in a mouse model of Dravet syndrome, a severe form of epilepsy.

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Illustration of a neuron on top of a marijuana leaf surrounded by psychadelic colors.

Cannabis and autism, explained

by  /  7 September 2020

Autistic people and their families are increasingly experimenting with marijuana to try to ease problems such as insomnia, epilepsy and chronic pain — and traits of autism. But there is little evidence for its safety or effectiveness.

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