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Spectrum: Autism Research News

Tag: mouse models

May 2022
Scientist Lucia Peixoto portrait.

Rising star: Lucia Peixoto, breaking down the interplay between sleep and autism

by  /  9 May 2022

The young researcher from Uruguay uses her expertise in genetics — and discipline as a former athlete — to untangle sleep’s role in neurodevelopmental conditions, one experiment at a time.

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SYNGAP1 protein boosts cognition, blocks seizures in mice

by  /  4 May 2022

Ramping up levels of one isoform of the autism-linked protein reverses traits in model mice, a new study shows.

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April 2022

Mice missing key clock gene show autism-like traits

by  /  28 April 2022

A new study is the first to link social, repetitive and motor behaviors to mutations in BMAL1, which regulates the body’s circadian rhythms.

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Mini biopsies point to source of lethal seizures in model mice

by  /  26 April 2022

Interneurons that fail to propagate electrical signals in mice that model Dravet syndrome may cause the animals, like people with the autism-linked condition, to die suddenly.

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Histone-modifying drug improves autism-like behaviors in mice

by  /  18 April 2022

The experimental compound, called GSK-LSD1, enhances social preferences and reduces repetitive grooming in mice, according to a new study.

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Micrographs comparing mouse striatal neurons missing TSHZ3 and wildtype striatal neurons.

Two groups of neurons govern autism-like traits in model mice

by  /  15 April 2022

Together, the neurons are part of the corticostriatal circuit, which has been implicated in autism.

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Faulty inhibition foils long-term memory in Rett mice

by  /  11 April 2022

The animals recall fear more readily if a set of inhibitory neurons in the hippocampus is switched on.

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Altering metabolic pathway spurs neuronal, behavioral changes in mice

by  /  5 April 2022

Overexpressing genes involved in the pathway, which regulates protein quality, changes repetitive behaviors in the animals.

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Open-source algorithm automates common marble-burying assay

by  /  1 April 2022

The machine-learning tool, which automatically counts how many marbles a mouse buries, appears to distinguish between hyperactivity and repetitive behaviors.

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March 2022

Unfamiliar surroundings bring out autism-like behaviors, brain circuit changes in model mice

by  /  31 March 2022

A brain area called the tail of the striatum may account for the shift.

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