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Spectrum: Autism Research News

Tag: mouse models

March 2023
Mother and child rhesus macaque monkeys.

Serotonin initiates earliest social bonds

by  /  2 March 2023

Mice and rats, for example, gravitate toward their mother’s bedding over bedding that is clean or smells of a different dam.

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Illustration of a gloved hand reaching down to place a pill bottle on a pedestal.

Debut drug for Rett syndrome at edge of approval

by  /  2 March 2023

The U.S. Food and Drug Administration plans to make an approval decision on the first-ever drug for girls and women with Rett syndrome by 12 March.

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February 2023
Research image showing the presence of several proteins in neurons.

Protein networks identified in autism-linked genetic deletion

by  /  28 February 2023

The OTUD7A gene, which may account for some traits in people missing a segment of chromosome 15, appears to interact with several known autism-linked genes.

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Illustration of a sheet of red and white pills, with the red pills arranged in the form of a question mark.

Going on Trial: Orphan drugs; CBD; bumetanide

by  /  28 February 2023

This month’s newsletter takes a close look at the orphan drug program in the United States, several cannabis-based therapies and a secondary analysis of bumetanide, among other new developments in autism-related drug trials.

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Research image of cell bodies of rett-like neurons, some of which were treated with epigenome editors.

Epigenome edits unmute MECP2 in Rett-like neurons

by  /  16 February 2023

The approach removes methyl tags from the gene and shields it from other silencing factors without changing the gene itself, raising hopes for a new treatment.

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Picture of a caged mouse with an EEG implanted.

Adult Angelman mice get some benefit from boosting UBE3A gene expression

by  /  9 February 2023

The treatment eases the animals’ sleep troubles, suggesting it has clinically meaningful effects beyond what was thought to be a critical window in early life.

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A white mouse, brown mouse and black mouse stand inside a wooden circle against a blue background.

CHD8 mutation in 33 mouse strains yields range of traits

by  /  3 February 2023

The findings put genetic background forward to help explain autism’s heterogeneity.

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January 2023
Research image showing neuronal activity in mice exposed to high-frequency sounds.

Missing mechanism helps solve fragile X protein mystery

by  /  24 January 2023

Cells from people with fragile X syndrome overproduce — but don’t accumulate — proteins. New work suggests that excessive protein breakdown may account for this discrepancy, and explain some of the syndrome’s traits.

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Jill Silverman sits at her desk with her dog.

Beyond the bench: Finding solitude with Jill Silverman

by  /  17 January 2023

The people-focused researcher shares her secrets to carving out time for grant writing, creating work-life balance and letting go of unread emails.

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Graham Diering smiles in a portrait in his yard.

Asleep in the Mouse House with Graham Diering

by  /  12 January 2023

Memories from Diering’s life trace the rising star’s scientific path from raising lizards as a child and later exploring home brewing to heading a lab that investigates memory, sleep disturbances and early development in animals with autism-linked mutations.

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