Deleting CHD8 from the intestines induces gastrointestinal and behavioral changes in mice that resemble traits in people with mutations in the gene.
Spectrum: Autism Research News
Tag: mouse models
A genetic therapy and an existing drug both restore typical brain size in mice missing DYRK1A, a top autism candidate gene, in the cerebral cortex, a new study shows. The animals typically have smaller brains than controls.
Anyone who uses multiple animals from a small number of litters to increase sample size is making a serious mistake. The similarities within individual litters will heavily skew the results.
Deleting the autism-linked gene CHD8 from specific cells in the cerebellum, a brain region important for movement, leads to motor deficits but does not alter social behaviors in mice.
Mutations in CUL3, a gene strongly linked to autism, may cause differences in brain structure by disrupting cytoskeleton proteins, according to a new study.
Too little — or too much — of certain substances during pregnancy may increase the odds of having a child with autism. Here we explain what scientists know about these associations.
Mice missing a copy of chromosomal region 16p11.2 are slow to learn motor tasks and have dysfunction in a brain circuit associated with stress and movement, according to a new study. Normalizing this circuit’s activity corrects the learning deficit.
A new atlas profiles gene activity early on during development in the human fetal brain.
Treating mice missing the autism-linked gene CNTNAP2 with a strain of gut bacteria makes them more social but no less hyperactive.