Excitatory and inhibitory neurons can derive from the same cellular source in the developing human brain, a new study suggests, overturning a 20-year-old hypothesis. Tomasz Nowakowski discusses the finding’s implications for autism research.
Spectrum: Autism Research News
Tag: mouse models
Infection during pregnancy can tweak a mouse’s gut microbiome in ways that have lasting effects on her pups’ immune system and increase their chances of gut inflammation, a new study suggests.
A new viral variant can deliver genes exclusively to the brain, overcoming a key hurdle in treating neurological conditions using gene therapy.
In mice with a mutated copy of SHANK3, stress induces social deficits and alters gene expression in certain excitatory neurons. But eliminating a stress-related protein that regulates SHANK3 restores typical social functioning in the animals.
New software can automatically identify and quantify mouse social behavior from videos, saving researchers time.
Deleting a copy of the gene TBX1 depletes the fatty myelin insulation that surrounds neurons and reduces cognitive speed in mice.
A potential new gene therapy delivered via a single injection mimics ratios of proteins normally found in cells.
Clues that problems with mitochondria contribute to autism have been accumulating for decades. In the past five years, a mutant mouse and a flurry of findings have energized the field.
An atypical thalamus may underlie not only sensory issues in autism but also difficulties with social skills, attention and memory.