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Spectrum: Autism Research News

Tag: mouse models

June 2021
Micrographs of mouse astrocytes with high levels of inflammatory molecules.

Immune-regulating cells contribute to autism-like traits in mice

by  /  21 June 2021

The link between autism and prenatal exposure to an immune response may involve altered levels of immune cells, according to a new study.

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Mouse neuron recordings showing different levels of activity before and after an encounter with an unfamiliar mouse.

Neural network captures noisy neurons in autism mouse model

by  /  18 June 2021

Mice missing the autism-linked gene SHANK3 use more neurons to engage in social behavior than control mice do, reflecting a more disorganized, less efficient brain signaling network.

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Illustration of transporter mice in brain maze

After 60 years, scientists are still trying to crack a mysterious serotonin-autism link

by  /  4 June 2021

The high levels of serotonin seen in the blood of some autistic people have confounded scientists for more than half a century. Despite so little progress, some researchers refuse to give up.

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Brown lab mice being handled by researchers.

Deleting rare autism gene leads to physical, social differences in mice

by  /  3 June 2021

Loss of the gene KMT5B stunts growth in male mice and leads to social difficulties in female mice, a new study suggests.

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Mini probe records neuronal activity in mouse brain over months

by  /  1 June 2021

A new miniature iteration of a popular probe enables researchers to record activity at thousands of sites across the mouse brain and track the activity of individual neurons over months — providing long-term recording at an unprecedented scale.

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May 2021
3D mouse rendering

Virtual mouse helps scientists track behavior

by  /  27 May 2021

An animated mouse reenacts common behavioral experiments and can be used to train algorithms that automatically track lab animals’ movements.

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Genes tied to autism, developmental delay, schizophrenia share functions

by  /  7 May 2021

Many genes linked to autism, schizophrenia and neurodevelopmental delay regulate gene expression and support communication between neurons.

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Mouse gut cells in blue, purple and pink

Loss of top autism-linked gene from gut alters behavior in mice

by  /  4 May 2021

Deleting CHD8 from the intestines induces gastrointestinal and behavioral changes in mice that resemble traits in people with mutations in the gene.

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April 2021
Two views of mouse brain slices colorized in green and red.

Jump-starting growth signaling reverses microcephaly in autism mouse model

by  /  29 April 2021

A genetic therapy and an existing drug both restore typical brain size in mice missing DYRK1A, a top autism candidate gene, in the cerebral cortex, a new study shows. The animals typically have smaller brains than controls.

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Female mouse with its litter of pups.

Few autism researchers control for the ‘litter effect’ — this needs to change

by ,  /  27 April 2021

Anyone who uses multiple animals from a small number of litters to increase sample size is making a serious mistake. The similarities within individual litters will heavily skew the results.

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