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Spectrum: Autism Research News

Tag: mouse models

March 2022

Autism model mice develop typical social and motor behaviors after drug treatment

by  /  9 March 2022

The drug suppresses an overactive signaling pathway implicated in tuberous sclerosis complex.

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Silenced X chromosome genes reawaken in new mouse model

by  /  3 March 2022

The new animal line could accelerate the discovery of gene-activating therapies for the autism-linked condition Rett syndrome.

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Brain floating in red uetero-like space with virus

As the pandemic wanes, will autism diagnoses rise in its wake?

by  /  2 March 2022

Given the known link between severe maternal infections and autism, some scientists are investigating whether COVID-19 during pregnancy can affect a child’s neurodevelopment.

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February 2022
Micrograph of neurons with excess neurons due to excess MECP2 expression.

Protein complex points to new route to Rett syndrome

by  /  18 February 2022

Mutations in a newly identified protein complex that interacts with the Rett protein also lead to a Rett-like condition in mice, researchers say.

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Top autism candidate gene tied to newly identified syndrome

by  /  17 February 2022

Mutations in the autism-linked gene PAX5 underlie a range of traits, including developmental delay, intellectual disability, seizures and autism.

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Gut molecule linked to decreased myelination in mouse brains

by  /  14 February 2022

Targeting the molecule, 4EPS, with an experimental drug may be a way to ease anxiety for autistic people, the researchers say. But not everyone is convinced.

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Dr. Kostas Zarbalis standing in front of a window in his office.

Beyond the bench: A conversation with Konstantinos Zarbalis

by  /  10 February 2022

Konstantinos “Kostas” Zarbalis talks about the upside of unexpected experimental results, and why he eats just one meal per day.

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Software automatically measures mouse's gait and posture by tracking various points on the mouse's body.

Algorithm spots subtle gait changes in autism mouse models

by  /  4 February 2022

By automatically quantifying gait and posture in videos of mice, a new machine-learning tool could accelerate research on how autism-linked mutations or drug treatments affect motor skills.

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Immune gene tied to social behavior in autism mouse model

by  /  3 February 2022

Activating the immune system blunts social behavior in mice missing a copy of the autism-linked gene SHANK3, according to a new study. Blocking TRPV4, which encodes an ion channel involved in inflammatory responses, can reverse this effect.

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Enrichment lessens Angelman-like traits in male mice

by  /  2 February 2022

Model animals don’t develop the usual behavioral and motor problems when reared in an enclosure containing exercise wheels, toys and treats.

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