Tag: mouse models

May 2018
Multimedia / Webinars

Journal club: Rescue of social deficits in autism mouse model

23 May 2018

Register for the next Spectrum journal club, featuring Zhen Yan, who will discuss a paper describing the rescue of social deficits in a SHANK3 mouse model.

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April 2018
News

CRISPR goes wild, and scientists debate its fidelity

by  /  30 April 2018

The gene-editing tool CRISPR may cause thousands of off-target mutations, but critics say it’s way too soon to accuse it of infidelity.

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News

Altered brain waves may underlie social problems in autism mice

by  /  16 April 2018

Boosting the activity of a class of neurons that dampen brain signals eases social problems in a mouse model of autism.

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News

Loss of autism gene makes mice sensitive to pain

by  /  9 April 2018

Mice lacking CNTNAP2, a gene strongly linked to autism, are acutely sensitive to pain.

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News

Gene in autism risk region plays key role in brain development

by  /  4 April 2018

Mice missing TAOK2, a gene in a segment of chromosome 16 linked to autism, have big brains, immature neuronal junctions and asocial behavior.

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March 2018
News

Gene on chromosome 16 may be valuable player in autism

by  /  29 March 2018

Deleting one copy of a gene called MVP impairs the brain's ability to adapt to changes in the environment.

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Multimedia / Podcasts

Spectrum Stories: Talking about autism mouse models

by  /  21 March 2018

Scientists discuss the problems with using mice to study autism, and explain how the field might move forward.

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Opinion / Viewpoint

How variability among mouse strains can aid autism research

by  /  21 March 2018

Researchers can convert the distinct genetic backgrounds of lab mice from a problem to an advantage, exploiting the differences to advance our understanding of autism.

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scientist looks through binoculars showing a boy on one side, and a mouse on the other.
Opinion / Viewpoint

Why we need a mouse version of a diagnostic test for autism

by ,  /  21 March 2018

Researchers have developed behavioral measures that can accurately diagnose autism in people; these lessons can and should be applied to mice.

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Mouse in a lab or maze hops around sniffing here and there
Features / Deep Dive

Why studying autism in mice may be doomed to fail

by  /  21 March 2018

After more than a decade of effort, scientists are questioning whether mouse models of autism can ever capture the social deficits seen in people with the condition.

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