In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Spectrum: Autism Research News
Tag: mouse models
Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.
Increasing or reducing the levels of the UBE3A gene, which is associated with autism and autism-related syndromes, results in altered patterns of synaptic pruning — a process that snips away brain cell connections.
A thin “micro-tether” and rotating connector facilitate uninterrupted, hours-long neural population recordings as the animals freely explore their environment.
Synaptic changes in the brain region could drive a core trait of fragile X syndrome, a new mouse study suggests.
A protective pathway that pauses protein synthesis is muted in a mouse model of fragile X syndrome, according to a new study.
Over one hour, a particularly motivated mouse poked its nose 350 times into a hole in the test chamber in the hopes of meeting a playmate.
The tool could help researchers study the neurobiology of natural behaviors, scientists say.