Skip to main content

Spectrum: Autism Research News

Tag: mouse models

May 2022
Ultrasound in black and white shows a pattern.

Heart anomalies abound in mouse models of autism

by  /  23 May 2022

Of nine genetic models examined in a new study, all had some incidence of cardiac abnormalities. But the problems varied widely depending on the affected genes.

0 Comments
Lab mice (Mus musculus), tribe Balbc, three 13 day old babies with eyes still closed, laying side by side

Sleepy mice with autism-linked mutation struggle to fall asleep

by  /  19 May 2022

Mice with a mutated copy of SHANK3 fail to establish normal sleep patterns during development.

0 Comments
White lab mice bunched up in corner of cage.

Mouse models mirror cerebellum patterns seen in autism

by  /  12 May 2022

Animals with different autism-linked mutations share disruptions to the mTOR signaling pathway, pointing to a potential molecular mechanism for the atypical cerebellar development seen in some autistic people.

0 Comments
Scientist Lucia Peixoto portrait.

Rising star: Lucia Peixoto, breaking down the interplay between sleep and autism

by  /  9 May 2022

The young researcher from Uruguay uses her expertise in genetics — and discipline as a former athlete — to untangle sleep’s role in neurodevelopmental conditions, one experiment at a time.

0 Comments

SYNGAP1 protein boosts cognition, blocks seizures in mice

by  /  4 May 2022

Ramping up levels of one isoform of the autism-linked protein reverses traits in model mice, a new study shows.

0 Comments
April 2022

Mice missing key clock gene show autism-like traits

by  /  28 April 2022

A new study is the first to link social, repetitive and motor behaviors to mutations in BMAL1, which regulates the body’s circadian rhythms.

0 Comments

Mini biopsies point to source of lethal seizures in model mice

by  /  26 April 2022

Interneurons that fail to propagate electrical signals in mice that model Dravet syndrome may cause the animals, like people with the autism-linked condition, to die suddenly.

0 Comments

Histone-modifying drug improves autism-like behaviors in mice

by  /  18 April 2022

The experimental compound, called GSK-LSD1, enhances social preferences and reduces repetitive grooming in mice, according to a new study.

0 Comments
Micrographs comparing mouse striatal neurons missing TSHZ3 and wildtype striatal neurons.

Two groups of neurons govern autism-like traits in model mice

by  /  15 April 2022

Together, the neurons are part of the corticostriatal circuit, which has been implicated in autism.

0 Comments

Faulty inhibition foils long-term memory in Rett mice

by  /  11 April 2022

The animals recall fear more readily if a set of inhibitory neurons in the hippocampus is switched on.

0 Comments