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Spectrum: Autism Research News

Tag: mouse models

September 2022
Brain slice of a mouse brain showing cells carrying the fragile X mutation.

Fragile X neurons develop atypically in chimeric mice

by  /  29 September 2022

After a brain transplant of reprogrammed human cells, the animals can for the first time recapitulate some neuronal changes seen in people with fragile X syndrome.

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Set of 6 scans shows mice recovering MECP2 protein in their brainstem after being treated with RNA-editing viruses.

RNA rewrite improves breathing, survival in Rett mice

by  /  22 September 2022

The technique involves editing the cellular instructions to make MECP2 protein and partially restores its levels in the brainstem.

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A brown lab mouse perches on a researcher's hand.

Largest-yet fragile X mutation in mice confirms model’s shortcomings

by  /  14 September 2022

A 341-repeat mutation from a person with fragile X does not lead to the syndrome’s traits or function the same way in mice, highlighting a need for different animal models.

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Brain scans demonstrating differences in mice with TBR1 mutations.

Mutation-specific models highlight autism’s heterogeneity

by  /  12 September 2022

The brains of mice carrying different mutations in the autism-linked gene TBR1 display different molecular changes yet similar structural changes, resembling those previously found in autistic people with TBR1 mutations.

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Lost sleep sparks lasting social problems in SHANK3 mice

by  /  12 September 2022

Sleep disruption early in life has long-lasting consequences for mice missing a copy of the autism-linked gene SHANK3.

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Lab mice (Mus musculus), tribe Balbc, three 13 day old babies with eyes still closed, laying side by side

Sleepy mice with autism-linked mutation struggle to fall asleep

by  /  12 September 2022

Mice with a mutated copy of SHANK3 fail to establish normal sleep patterns during development.

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An illustration of two scientists carrying a larger-than-life DNA strand on their shoulders.

Community Newsletter: Autism gene lists, genetic diversity in mouse models, an autism biomarker

by  /  4 September 2022

This week, we’re bringing you some labors of love: a thread lamenting the autism field’s focus on gene lists, a study introducing genetic diversity in mouse models, and long-awaited results from a biomarker study.

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August 2022
Scientist Gül Dölen smiles while looking towards the window in her lab's office.

In deep water with Gül Dölen

by  /  3 August 2022

A researcher’s existential crisis led to a scientific breakthrough.

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Of mice and human interneurons: A Q&A with Moritz Helmstaedter

by  /  1 August 2022

People’s brains have a larger network of inhibitory interneurons than mouse brains do, according to a new study. Changes to that network could contribute to autism or other conditions, says lead investigator Moritz Helmstaedter.

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July 2022

New software flags autism rat model’s telltale squeaks

by  /  29 July 2022

By breaking rodent vocalizations into parts, TrackUSF distinguishes rats with mutations in the SHANK3 gene from their wildtype counterparts.

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