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Tag: mouse models

November 2020
SYNGAP1 protein between neurons.
News

Reactions from the 2020 SYNGAP1 Scientific Conference

by  /  24 November 2020

Spectrum is covering the 2020 International SYNGAP1 Scientific Conference, which took place virtually because of the coronavirus pandemic. Here we’re highlighting researchers’ reactions to noteworthy presentations.

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Dilated mouse pupil
News

Mice reveal roots of sensory issues tied to top autism gene

by  /  23 November 2020

Mice with mutations in the autism-linked gene SYNGAP1 have trouble sensing touch, which may stem in part from brain-circuit alterations and dulled alertness.

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Micrograph of nerve cells being targeted by CRISPR enzyme to activate the silenced gene in Angelman syndrome
News

Prenatal CRISPR therapy blocks Angelman syndrome traits in mice

by  /  9 November 2020

A gene-editing treatment shows long-lasting effects in a mouse model of Angelman syndrome, a genetic condition related to autism.

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Fifteen different drugs commonly prescribed to people with autism created unique behavioral signatures in mice.
News

‘MoSeq’ identifies drug-specific behaviors in autism mouse model

by  /  2 November 2020

A tool that relies on video cameras and machine learning can identify mice that have mutations in a top autism gene by their behaviors. It also detects how a widely used autism drug affects their movements.

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October 2020
White mouse grooming.
News

Nighttime light affects sleep, repetitive behaviors in autism mouse model

by  /  5 October 2020

Mice missing an autism gene groom themselves more than usual and have altered circadian rhythms after nighttime exposure to light.

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September 2020
White lab mouse sitting in a gloved hand.
News

Silencing ‘poison exon’ eliminates deadly seizures in mice

by  /  24 September 2020

A new treatment curbs deadly seizures in a mouse model of Dravet syndrome, a severe form of epilepsy.

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Illustration of a neuron on top of a marijuana leaf surrounded by psychadelic colors.
News

Cannabis and autism, explained

by  /  7 September 2020

Autistic people and their families are increasingly experimenting with marijuana to try to ease problems such as insomnia, epilepsy and chronic pain — and traits of autism. But there is little evidence for its safety or effectiveness.

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Zebrafish embryos with various deformities.
News / Toolbox

CRISPR technique knocks down gene expression in animal embryos

by  /  2 September 2020

A new method that suppresses gene expression in the embryos of fish and mice may help researchers study autism genes in early development.

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August 2020
Two mice side-by-side.
News

Drug improves social behaviors, oxytocin signaling in autism mouse model

by  /  31 August 2020

Mice missing the autism gene NLGN3 have altered social behaviors and brain responses to the hormone oxytocin, both of which improve after treatment with a drug that helps regulate protein production.

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RNA, transcription
News

Antidote to ‘poison’ DNA may treat lethal form of epilepsy

by  /  26 August 2020

An experimental drug silences a DNA segment and seems to prevent seizures and death in a condition related to autism.

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