Tag: mouse models

June 2018
eight brains with various sections highlighted
News

Chromosome 16 deletion miswires brain in people, mice

by  /  12 June 2018

Mice and people missing a copy of a chromosomal region called 16p11.2 show similar patterns of weak brain connections.

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News

Mice missing top autism gene have overconnected brains

by  /  11 June 2018

Mice with one inactivated copy of CHD8, a top autism gene, show an unusually high degree of synchrony in neural activity between brain regions.

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News

Chromosome 16’s role in brain, behavior varies by sex

by  /  1 June 2018

Female mice may compensate for the loss of a piece of chromosome 16 better than male mice do.

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May 2018
Multimedia / Webinars

Journal club: Rescue of social deficits in autism mouse model

23 May 2018

Watch the complete replay of this journal club, which featured a paper describing the rescue of social deficits in a SHANK3 mouse model.

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April 2018
four scientists standing on colorful tile
News

CRISPR goes wild, and scientists debate its fidelity

by  /  30 April 2018

The gene-editing tool CRISPR may cause thousands of off-target mutations, but critics say it’s way too soon to accuse it of infidelity.

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Two mice against black background
News

Altered brain waves may underlie social problems in autism mice

by  /  16 April 2018

Boosting the activity of a class of neurons that dampen brain signals eases social problems in a mouse model of autism.

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CASPR2 antibodies (green) bind to sensory neurons that send signals to the spinal cord (right) but not to neurons in the spinal cord (left).
News

Loss of autism gene makes mice sensitive to pain

by  /  9 April 2018

Mice lacking CNTNAP2, a gene strongly linked to autism, are acutely sensitive to pain.

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A bundle of nerves connecting the brain’s hemispheres is thinner in mice missing TAOK2 (right) than in controls (left).
News

Gene in autism risk region plays key role in brain development

by  /  4 April 2018

Mice missing TAOK2, a gene in a segment of chromosome 16 linked to autism, have big brains, immature neuronal junctions and asocial behavior.

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March 2018
closeup of a mouse eye
News

Gene on chromosome 16 may be valuable player in autism

by  /  29 March 2018

Deleting one copy of a gene called MVP impairs the brain's ability to adapt to changes in the environment.

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Multimedia / Podcasts

Spectrum Stories: Talking about autism mouse models

by  /  21 March 2018

Scientists discuss the problems with using mice to study autism, and explain how the field might move forward.

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