A new atlas profiles gene activity early on during development in the human fetal brain.
Spectrum: Autism Research News
Tag: mouse models
Treating mice missing the autism-linked gene CNTNAP2 with a strain of gut bacteria makes them more social but no less hyperactive.
Mutations in CHD8 lead to brain overgrowth or undergrowth in mice, depending on how they affect the gene’s expression.
Motor and memory training early in life postpones the onset of difficulties in those areas in a mouse model of Rett syndrome, and stimulating neurons involved in those skills appears to mimic the effects of training.
A typically protective stress response could help to explain the connection between maternal illness and neurodevelopmental conditions.
Altering a protein linked to Rett syndrome so that it cannot bind to a methylation tag in neurons results in Rett-like traits in mice.
Misaligned gene expression maps suggest that some autism-linked genes play distinct roles in mouse and human brains.