Tag: mouse models

May 2018
Multimedia / Webinars

Journal club: Rescue of social deficits in autism mouse model

23 May 2018

Watch the complete replay of this journal club, which featured a paper describing the rescue of social deficits in a SHANK3 mouse model.

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April 2018
four scientists standing on colorful tile
News

CRISPR goes wild, and scientists debate its fidelity

by  /  30 April 2018

The gene-editing tool CRISPR may cause thousands of off-target mutations, but critics say it’s way too soon to accuse it of infidelity.

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Two mice against black background
News

Altered brain waves may underlie social problems in autism mice

by  /  16 April 2018

Boosting the activity of a class of neurons that dampen brain signals eases social problems in a mouse model of autism.

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CASPR2 antibodies (green) bind to sensory neurons that send signals to the spinal cord (right) but not to neurons in the spinal cord (left).
News

Loss of autism gene makes mice sensitive to pain

by  /  9 April 2018

Mice lacking CNTNAP2, a gene strongly linked to autism, are acutely sensitive to pain.

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A bundle of nerves connecting the brain’s hemispheres is thinner in mice missing TAOK2 (right) than in controls (left).
News

Gene in autism risk region plays key role in brain development

by  /  4 April 2018

Mice missing TAOK2, a gene in a segment of chromosome 16 linked to autism, have big brains, immature neuronal junctions and asocial behavior.

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March 2018
closeup of a mouse eye
News

Gene on chromosome 16 may be valuable player in autism

by  /  29 March 2018

Deleting one copy of a gene called MVP impairs the brain's ability to adapt to changes in the environment.

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Spectrum stories podcast logo
Multimedia / Podcasts

Spectrum Stories: Talking about autism mouse models

by  /  21 March 2018

Scientists discuss the problems with using mice to study autism, and explain how the field might move forward.

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Opinion / Viewpoint

How variability among mouse strains can aid autism research

by  /  21 March 2018

Researchers can convert the distinct genetic backgrounds of lab mice from a problem to an advantage, exploiting the differences to advance our understanding of autism.

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scientist looks through binoculars showing a boy on one side, and a mouse on the other.
Opinion / Viewpoint

Why we need a mouse version of a diagnostic test for autism

by ,  /  21 March 2018

Researchers have developed behavioral measures that can accurately diagnose autism in people; these lessons can and should be applied to mice.

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Mouse in a lab or maze hops around sniffing here and there
Features / Deep Dive

Why studying autism in mice may be doomed to fail

by  /  21 March 2018

After more than a decade of effort, scientists are questioning whether mouse models of autism can ever capture the social deficits seen in people with the condition.

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