Top autism-linked genes join forces to shape synaptic plasticity
The protein products of ANK2 and SCN2A interact to regulate dendritic excitability.
The protein products of ANK2 and SCN2A interact to regulate dendritic excitability.
Random fluctuations in neuronal activity are more variable in a fragile X mouse model than in wildtype mice.
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
The tool — called “MouseGoggles” — could provide rodents with an improved virtual experience in the lab, at a lower cost than current techniques.
The mutations disrupt protein translation as well as the cell’s skeleton, according to a new study.
Synaptic changes in the brain region could drive a core trait of fragile X syndrome, a new mouse study suggests.
A protective pathway that pauses protein synthesis is muted in a mouse model of fragile X syndrome, according to a new study.
Over one hour, a particularly motivated mouse poked its nose 350 times into a hole in the test chamber in the hopes of meeting a playmate.
The tool could help researchers study the neurobiology of natural behaviors, scientists say.
When combined with tissue-inflation methods, the microscope can image axons without the need for tissue slicing, the researchers say.