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Spectrum: Autism Research News

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Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

April 2022
organoids in early stages of development.

Organoids show how mutations in top autism gene may lead to brain overgrowth in people

by  /  19 April 2022

The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.

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Histone-modifying drug improves autism-like behaviors in mice

by  /  18 April 2022

The experimental compound, called GSK-LSD1, enhances social preferences and reduces repetitive grooming in mice, according to a new study.

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Fruit flies help reveal effects of autism-linked mutations

by  /  13 April 2022

Dozens of rare mutations of unknown effects seen in autistic people cause significant changes to fruit flies, suggesting they are linked to the condition.

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Faulty inhibition foils long-term memory in Rett mice

by  /  11 April 2022

The animals recall fear more readily if a set of inhibitory neurons in the hippocampus is switched on.

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Altering metabolic pathway spurs neuronal, behavioral changes in mice

by  /  5 April 2022

Overexpressing genes involved in the pathway, which regulates protein quality, changes repetitive behaviors in the animals.

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March 2022

DNA tags in placenta point to possible autism-linked gene

by  /  29 March 2022

The gene, dubbed NHIP, is in a chromosomal region that shows unusually low levels of DNA methylation in placentas from women who gave birth to autistic children.

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Lisa Croen: Autism’s first dedicated epidemiologist

by  /  28 March 2022

Inspired by watching her autistic nephew grow up, Croen has also been an advocate for bolstering research and services for autistic adults.

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Neurons with low levels of ASH1L have fewer and shorter projections

Drug boosts growth of neurons deficient in autism-linked protein

by  /  25 March 2022

The neurons, which have low levels of the gene ASH1L, sprout more branches after the treatment.

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Web-based autism screening service raises a host of concerns

by  /  21 March 2022

Neurona Health, a company in San Francisco, California, backed away from part of its newly launched services after Spectrum started reporting about them.

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Autism model mice develop typical social and motor behaviors after drug treatment

by  /  9 March 2022

The drug suppresses an overactive signaling pathway implicated in tuberous sclerosis complex.

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