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Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

October 2019
News

Researchers debut mouse model for new autism gene

by  /  23 October 2019

Mice lacking one copy of a gene called DDX3X have developmental delay and sensory, motor and behavioral problems — similar to those seen in people with a mutation in the gene.

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Two male finches sitting on roost in cage.
News

Protein linked to autism may help birds learn songs from elders

by  /  23 October 2019

Turning down the expression of a gene linked to autism leaves zebra finches singing disorganized songs.

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News

Gene-edited marmosets may mimic Rett syndrome traits

by  /  23 October 2019

Researchers have used the gene-editing tool CRISPR to disable the MECP2 gene in marmoset embryos. The six such marmosets created seem to recapitulate aspects of Rett syndrome.

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Two pairs of neurons shown in red.
News

Gene editing rids mice of DNA segment linked to autism

by  /  23 October 2019

Researchers have used a new gene-editing technique to delete a segment of DNA associated with autism and schizophrenia from mouse brain cells.

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Opinion / Viewpoint

Angelman syndrome’s silent gene points way forward for autism therapies

by  /  21 October 2019

Advances in research and help from families have brought scientists to the brink of an effective therapy for Angelman syndrome.

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linked hands in a pattern intertwined with DNA showing some broken parts, symbolizing mutations
News

Rett syndrome’s link to autism, explained

by  /  21 October 2019

Studies of Rett syndrome hint at genes, cells and brain circuits that may be involved in autism — and may pave the way to treatments for both conditions.

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Neurons in a mouse brain are highlighted green and yellow
News

Autism gene’s loss hampers neurons’ trek through developing brain

by  /  21 October 2019

Deleting an autism gene called TRIO derails neurons’ journey to their destination.

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Two dark brown research mice
News

Mice with autism mutation reflect social difficulties seen in people

by  /  21 October 2019

A new autism mouse model carries the same mutation in a gene called ADNP that is seen in autistic people.

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DNA
News

Rapid assay flags autism mutations in regions that flank genes

by  /  21 October 2019

Researchers have identified mutations within regulatory regions that are likely to contribute to autism, using a speedy system of DNA ‘barcodes.’

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News

Maternal infection may accelerate expression of autism genes

by  /  21 October 2019

Exposure to infection in utero may speed up the expression of many genes linked to autism — and hasten changes in brain anatomy.

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