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Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

May 2021
Opinion / Q&A

Q&A with Sébastien Jacquemont and Clara Moreau: Why brain imaging signatures for autism are so elusive

by  /  20 May 2021

The field of neuroimaging will need to combine two strategies before it can find patterns of brain activity or structure unique to autism, the researchers say.

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Microglia activity seen in red, green and blue.
News

Autism mutation may cause big brain via ‘don’t eat me’ signals

by  /  17 May 2021

An autism-linked mutation could make the brain grow unusually large by prompting cells to express a chemical signal better known for its connection to cancer.

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News

Autism-linked protein screen reveals hundreds of new interactions

by  /  14 May 2021

Researchers have uncovered more than 1,200 new protein-protein interactions involving proteins coded for by autism-linked genes.

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Teen girl up at night, looking at her computer.
News

Childhood autism traits linked to hypomania in adolescence

by  /  10 May 2021

Children with autism traits tend to show agitation, excitability, decreased sleep and other mild signs of mania in adolescence; the association is higher in identical twins than fraternal twins, suggesting that genetics plays a role.

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News

Genes tied to autism, developmental delay, schizophrenia share functions

by  /  7 May 2021

Many genes linked to autism, schizophrenia and neurodevelopmental delay regulate gene expression and support communication between neurons.

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Neurons in red and green
News

‘Neurons on a chip’ reveal patterns across autism-linked conditions

by  /  7 May 2021

Activity patterns of neuronal networks link different genetic subtypes of autism that have similar traits, according to new unpublished research.

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Computer screenshot showing bands of colour resulting from sequenced DNA.
News

Largest autism genetics analysis to date uncovers more high-confidence candidates

by  /  6 May 2021

The largest-yet study of genetic data from autistic people has identified 255 genes associated with the condition.

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Chart compiling the deletions and duplications linked to various neurodevelopmental traits.
News

Massive analysis scores genes’ sensitivity to mutations

by  /  5 May 2021

Researchers have rated more than 17,000 genes, including many linked to autism and other neuropsychiatric conditions, according to their sensitivity to deletions and duplications.

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Computer screen reflection in spectacles of DNA profile, close up of face
News

New ranking system flags clinically relevant ‘autism genes’

by  /  5 May 2021

A novel method to evaluate the strength of the evidence linking autism to specific genes could reveal which ones are most useful to screen for.

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Mouse gut cells in blue, purple and pink
News

Loss of top autism-linked gene from gut alters behavior in mice

by  /  4 May 2021

Deleting CHD8 from the intestines induces gastrointestinal and behavioral changes in mice that resemble traits in people with mutations in the gene.

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