Rare or common, inherited or spontaneous, mutations form the core of autism risk.
Mice missing a copy of the autism-linked gene PTEN show a reduced preference for social interaction, possibly due to atypically large, overconnected dopamine neurons. Easing the overconnection may alleviate this trait.
Mutations in the autism-linked gene ASH1L change how neurons grow and develop.
Mutations seen in only some of the body’s cells often affect gene activity in the brains of people with autism, and can involve large segments of DNA, according to two new studies.
Mice missing a copy of the autism-linked gene NRXN1 appear to perceive some time intervals as shorter than control mice do, according to a new study.
The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.
Mutations in autism-linked genes lead to a variety of changes in brain activity, sensory perception and sleep-wake cycles in zebrafish.
A new technique for masking portions of raw genomic data increases shareability without sacrificing privacy.
A pair of new atlases that profile millions of cells across 15 organs offer an unparalleled look at gene activity during fetal development.
Mutations in POGZ, a gene strongly linked to autism, lead to a signaling imbalance in multiple brain regions in mice, according to two new studies.
Gene therapies and the factors influencing autism traits top Spectrum’s list of the 10 most notable research findings we covered in 2020.
