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Spectrum: Autism Research News

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Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

July 2022

New resource maps gene expression, regulation in neuron subtypes

by  /  1 July 2022

The catalog could help researchers understand the effects of autism-linked DNA variants that fall outside genes.

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June 2022
Illustration of a pregnant woman in a peach-colored shirt and light red pants standing in profile against a backdrop of chromosomes

Autism linked to inflammatory bowel disease in parents

by  /  28 June 2022

The inflammation associated with the disease, particularly in mothers, may contribute to autism traits in children.

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A computer-rendered analysis of neurons

Autism-linked mutation disrupts brain circuit to change social behavior

by  /  24 June 2022

Therapies that target the circuit could boost social activity, new findings suggest.

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Illustration of two figures in a field of black circles representing genetic risks. The circles surround the figure on the left and stay farther away from the figure on the right.

Common inherited variants tied to autism show sex bias in families

by  /  23 June 2022

Siblings of autistic females are more likely to have autism than siblings of autistic males are, and mothers of autistic children carry more common, autism-linked variants than fathers do.

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Mice without DDX3X are slow to grow neurons

by  /  17 June 2022

The gene helps neurons exit the cell-maturation cycle during fetal brain development, a new study shows. But male and female mice respond differently to DDX3X loss.

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Gene therapy targets interneurons to tackle Dravet syndrome

by  /  13 June 2022

The approach, tested in mice, selectively boosts the expression of the autism-linked gene SCN1A in a subgroup of inhibitory cells.

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Different forms of autism have opposite problems with brain precursor cells

by  /  10 June 2022

The cells’ altered proliferation rates hint at ways to diagnose and potentially treat autism earlier.

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Two top autism-linked proteins connect to build cell ‘skeleton’

by  /  9 June 2022

ADNP and SHANK3 proteins may bind together and alter a neuron’s internal scaffold, hinting at a mechanism that, when disrupted, may underlie several forms of autism.

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black-and-white image of a burst of neuron activity, indicated by the neurons flashing brightly and simultaneously

Autism-linked mutation alters neuronal network activity

by  /  7 June 2022

Neurons with a faulty copy of SETD1A, a gene tied to autism and schizophrenia, show structural abnormalities and altered connectivity patterns.

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A street crowded with pedestrian traffic

Spectrum of variants contribute differently to autism traits

by  /  3 June 2022

Different combinations of common, rare, inherited and spontaneous mutations may explain why traits vary so widely among autistic people.

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