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Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

October 2019
Two pairs of neurons shown in red.
News

Gene editing rids mice of DNA segment linked to autism

by  /  23 October 2019

Researchers have used a new gene-editing technique to delete a segment of DNA associated with autism and schizophrenia from mouse brain cells.

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Opinion / Viewpoint

Angelman syndrome’s silent gene points way forward for autism therapies

by  /  21 October 2019

Advances in research and help from families have brought scientists to the brink of an effective therapy for Angelman syndrome.

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linked hands in a pattern intertwined with DNA showing some broken parts, symbolizing mutations
News

Rett syndrome’s link to autism, explained

by  /  21 October 2019

Studies of Rett syndrome hint at genes, cells and brain circuits that may be involved in autism — and may pave the way to treatments for both conditions.

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Neurons in a mouse brain are highlighted green and yellow
News

Autism gene’s loss hampers neurons’ trek through developing brain

by  /  21 October 2019

Deleting an autism gene called TRIO derails neurons’ journey to their destination.

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Two dark brown research mice
News

Mice with autism mutation reflect social difficulties seen in people

by  /  21 October 2019

A new autism mouse model carries the same mutation in a gene called ADNP that is seen in autistic people.

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DNA
News

Rapid assay flags autism mutations in regions that flank genes

by  /  21 October 2019

Researchers have identified mutations within regulatory regions that are likely to contribute to autism, using a speedy system of DNA ‘barcodes.’

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News

Maternal infection may accelerate expression of autism genes

by  /  21 October 2019

Exposure to infection in utero may speed up the expression of many genes linked to autism — and hasten changes in brain anatomy.

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News

Unusual gait marks mice with mutations related to autism

by  /  20 October 2019

Mouse models of two genetic conditions related to autism show abnormalities in their movement patterns.

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News

Transplanted neurons rescue social behavior but not brain circuits

by  /  20 October 2019

Injecting cells called interneurons into the brains of a mouse model of autism restores typical social behavior. But the reason for this effect is a puzzle.

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News

CRISPR therapy may reverse autism mutation’s effects well past infancy

by  /  20 October 2019

Injecting the gene-editing tool CRISPR into the brains of mice may reverse the effects of an autism mutation at any age.

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