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Spectrum: Autism Research News

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Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

November 2022
Single astrocyte on black background.

Mouse studies cast astrocytes as stars of sensory perception

by  /  13 November 2022

Data from two separate research teams suggest the cells are key to sensory hypersensitivity in fragile X syndrome.

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Photograph of a parent crossing a city street with two children

A mix of common and rare variants shapes autism inheritance patterns

by  /  4 November 2022

The study also reveals a link between language development and common variants.

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Three scans of zebrafish brains.

Zebrafish point to new gene involved in brain overgrowth, autism

by  /  1 November 2022

The gene, YTHDF2, has not previously been linked to autism.

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October 2022
Woman sits on a hospital bed and looks out of a window.

Psychiatric conditions hospitalize almost one in three autistic women by age 25

by  /  31 October 2022

The findings, based on Swedish national registry data, suggest a critical need to expand mental health services for autistic people.

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New RNA tool prompts protein production in select cells

by  /  28 October 2022

The technique could be used to identify and control cells involved in autism.

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Image of a synthetic mouse embryo.

Lab-grown ‘embryoids’ offer new window into gene-trait relationships

by  /  26 October 2022

The developmental models have advantages over natural embryos and other synthetic models, such as organoids, but present technical and ethical challenges.

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Conceptual illustration of a group of brain scans.

Boosting brain power: A conversation with Damien Fair

by  /  25 October 2022

Collecting brain scans from thousands of people can be challenging in autism research; data-sharing and collaborative efforts can help drive results that stand up to statistical scrutiny.

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Illustration of an X chromosome against a black background.

X-chromosome variants help explain autism’s sex bias

by  /  24 October 2022

The rare variants are also linked to ADHD and Tourette syndrome, two other conditions that disproportionately affect boys and men.

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Jeremy Levin, chief executive officer of Ovid Therapeutics, stands against a bench in a lab.

What next for Angelman?

by  /  20 October 2022

A meeting in Texas reckons with the future of treatment, following two setbacks in 2020.

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Mouse brain slices showing the effects of SHANK2 and SHANK3 deletions.

Double SHANK knockout highlights brain circuit’s social role

by  /  19 October 2022

Mice missing the autism-linked SHANK2 and SHANK3 genes in their retrosplenial cortex have trouble distinguishing between novel and familiar mice.

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