TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

October 2018
An illustration shows a mosaic-like view of viruses delivering genes to the brain.
Opinion / Viewpoint

Angelman syndrome: Bellwether for genetic therapy in autism

by ,  /  16 October 2018

It is not a matter of whether there will be clinical trials of genetic therapy for Angelman syndrome, but when.

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Two children picking mushrooms in a field.
News

Genetics plays outsized role in autism, large study shows

by  /  15 October 2018

Autism is more heritable than anorexia, alcohol dependence, depression and obsessive-compulsive disorder, according to an analysis of data from nearly 4.5 million people.

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News / Toolbox

Rapid method connects DNA shape to gene activity in cells

by  /  12 October 2018

A new technique reveals the active genes and the regions that regulate them in thousands of single cells at once.

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Juan Pablo Quintero, Sara Quintero, Soledad Quintero, Rosario Quintero, Yeison Quintero, pose for a group portrait in Ricaurte, Valle del Cauca, on July 28, 2018.
Features / Deep Dive

Unlocking the secrets of fragile X in Colombia

by  /  10 October 2018

A remote Colombian town is home to the world’s largest cluster of people with fragile X syndrome. Scientists are learning from them — and trying to help.

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Illustration of human brain in brackets suggesting circuit alterations that is associated with certain genetic mutations.
Opinion / Viewpoint

Brain scans of sleeping mice hint at subtypes of autism

by  /  9 October 2018

Mapping the effects of autism mutations on mouse brain circuits may reveal subtypes of the condition in people.

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Modifier genes may enhance or diminish the effects of a mutation linked to autism.
News

Second ‘hits’ may explain autism mutations’ varied effects

by  /  5 October 2018

People who have a mutation linked to autism plus a second genetic glitch tend to have more severe symptoms than those with the mutation alone.

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DNA helix with two mutations glowing blue on the helices. Rebecca Horne
News

Study links subset of genetic variants to autism, intellectual disability

by  /  3 October 2018

Genetic variants across the genome contribute to about 8 percent of the risk for certain developmental conditions — much more than previously thought.

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September 2018
A collage of a DNA helix with two of the bars showing a different color. by Rebecca Horne
News

Control of gene expression alters impact of autism mutations

by  /  27 September 2018

Variants that control gene expression are often involved in whether a mutation ends up being harmful, and how harmful it is.

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Drawing shows scientists moving in different directions in a matrix of molecules and and genetic material.
News

Newly discovered aspects of fragile X spur next wave of drugs

by  /  24 September 2018

Many drugs for fragile X syndrome have failed in large clinical trials, but candidates that target new aspects of the condition may fare better.

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Three games on a table, bead mazes.
News

How genetics is revealing rare childhood conditions

by ,  /  21 September 2018

A pioneering project is showing how, 17 years since the first draft of the human genome, our genes are giving up their secrets and bringing hope to parents around the world.

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