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Spectrum: Autism Research News

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Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

April 2022

Mice missing key clock gene show autism-like traits

by  /  28 April 2022

A new study is the first to link social, repetitive and motor behaviors to mutations in BMAL1, which regulates the body’s circadian rhythms.

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Mini biopsies point to source of lethal seizures in model mice

by  /  26 April 2022

Interneurons that fail to propagate electrical signals in mice that model Dravet syndrome may cause the animals, like people with the autism-linked condition, to die suddenly.

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Book cover conceptual illustration of chromosome superimposed with genetic tree.

A whisper of autism: Fragile X carriers and the autism phenotype

by  /  21 April 2022

Among people who carry the fragile X premutation, about 14 percent of boys and 5 percent of girls meet the criteria for autism, but the ‘broad autism phenotype’ may be far more common.

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organoids in early stages of development.

Organoids show how mutations in top autism gene may lead to brain overgrowth in people

by  /  19 April 2022

The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.

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Histone-modifying drug improves autism-like behaviors in mice

by  /  18 April 2022

The experimental compound, called GSK-LSD1, enhances social preferences and reduces repetitive grooming in mice, according to a new study.

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Fruit flies help reveal effects of autism-linked mutations

by  /  13 April 2022

Dozens of rare mutations of unknown effects seen in autistic people cause significant changes to fruit flies, suggesting they are linked to the condition.

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Faulty inhibition foils long-term memory in Rett mice

by  /  11 April 2022

The animals recall fear more readily if a set of inhibitory neurons in the hippocampus is switched on.

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Altering metabolic pathway spurs neuronal, behavioral changes in mice

by  /  5 April 2022

Overexpressing genes involved in the pathway, which regulates protein quality, changes repetitive behaviors in the animals.

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March 2022

DNA tags in placenta point to possible autism-linked gene

by  /  29 March 2022

The gene, dubbed NHIP, is in a chromosomal region that shows unusually low levels of DNA methylation in placentas from women who gave birth to autistic children.

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Lisa Croen: Autism’s first dedicated epidemiologist

by  /  28 March 2022

Inspired by watching her autistic nephew grow up, Croen has also been an advocate for bolstering research and services for autistic adults.

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