TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

November 2017
Mice that lack UBE3A only in their inhibitory neurons are particularly susceptible to seizures.
News

Gene therapy technique prevents seizures in Angelman mice

by  /  12 November 2017

Introducing the gene UBE3A into neurons that dampen brain activity prevents seizures in a mouse model of Angelman syndrome.

0 Comments
Brain regions (yellow) altered by missing immune genes correlate with those involved in anxiety.
News

Imaging study links immune genes to anxiety

by  /  12 November 2017

Mice missing any of 11 genes involved in the immune response show differences in brain anatomy that track with anxiety.

0 Comments
Zebrafish form large groups, called shoals,
News

SHANK3 zebrafish may be too cool for schools

by  /  12 November 2017

Zebrafish lacking the autism-linked gene SHANK3 show little social interest and other behavioral abnormalities.

0 Comments
united states capitol against reflection
News

Reactions from SfN 2017

by  /  9 November 2017

Spectrum heads to Washington, D.C., to cover the annual Society for Neuroscience conference.

1 Comment
Stack of filing boxes with papers going from one to another.
News

Registry for autism-linked syndrome spurs new research

by  /  2 November 2017

Nine U.S. clinics are pooling their data to create a registry of people who have an extra copy of a region on chromosome 15 called 15q11-13, a genetic abnormality often found in people with autism.

0 Comments
October 2017
Medical practitioner marking blood sample.
News

Mosaic mutations in sperm point to increased autism risk

by  /  23 October 2017

More than 5 percent of mutations thought to have arisen spontaneously in a child with autism may in fact be inherited.

1 Comment
A new resource charts the locations of two types of chemical modifications to chromosomes (top, middle) and gene expression changes (bottom) in brain tissue.
News / Toolbox

Databases describe DNA ‘dials’ that control gene expression

by  /  20 October 2017

Two new resources catalog how genetic variants affect gene expression in the brain.

0 Comments
Mother and daughter practicing writing.
News

Rare autism mutations linked to low intelligence

by  /  20 October 2017

People with autism who have rare, damaging mutations tend to have low scores on intelligence tests.

1 Comment
Boy staring at fidget spinner
News

Risk genes for autism overlap with those for attention deficit

by  /  20 October 2017

People with attention deficit hyperactivity disorder may carry certain rare, harmful mutations in many of the same genes as people with autism.

0 Comments
Boy and toddler sitting on sofa.
News

Data do-over backs dominance of genetics in autism risk

by  /  19 October 2017

A reanalysis of data from more than 2 million children in Sweden suggests inherited genetic factors account for 83 percent of autism risk.

3 Comments
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