A new study is the first to link social, repetitive and motor behaviors to mutations in BMAL1, which regulates the body’s circadian rhythms.
Spectrum: Autism Research News
Rare or common, inherited or spontaneous, mutations form the core of autism risk.
Interneurons that fail to propagate electrical signals in mice that model Dravet syndrome may cause the animals, like people with the autism-linked condition, to die suddenly.
Among people who carry the fragile X premutation, about 14 percent of boys and 5 percent of girls meet the criteria for autism, but the ‘broad autism phenotype’ may be far more common.
The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.
The experimental compound, called GSK-LSD1, enhances social preferences and reduces repetitive grooming in mice, according to a new study.
Dozens of rare mutations of unknown effects seen in autistic people cause significant changes to fruit flies, suggesting they are linked to the condition.
The animals recall fear more readily if a set of inhibitory neurons in the hippocampus is switched on.
Overexpressing genes involved in the pathway, which regulates protein quality, changes repetitive behaviors in the animals.
The gene, dubbed NHIP, is in a chromosomal region that shows unusually low levels of DNA methylation in placentas from women who gave birth to autistic children.
Inspired by watching her autistic nephew grow up, Croen has also been an advocate for bolstering research and services for autistic adults.