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Spectrum: Autism Research News

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Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

April 2022

Fruit flies help reveal effects of autism-linked mutations

by  /  13 April 2022

Dozens of rare mutations of unknown effects seen in autistic people cause significant changes to fruit flies, suggesting they are linked to the condition.

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Faulty inhibition foils long-term memory in Rett mice

by  /  11 April 2022

The animals recall fear more readily if a set of inhibitory neurons in the hippocampus is switched on.

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Altering metabolic pathway spurs neuronal, behavioral changes in mice

by  /  5 April 2022

Overexpressing genes involved in the pathway, which regulates protein quality, changes repetitive behaviors in the animals.

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March 2022

DNA tags in placenta point to possible autism-linked gene

by  /  29 March 2022

The gene, dubbed NHIP, is in a chromosomal region that shows unusually low levels of DNA methylation in placentas from women who gave birth to autistic children.

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Lisa Croen: Autism’s first dedicated epidemiologist

by  /  28 March 2022

Inspired by watching her autistic nephew grow up, Croen has also been an advocate for bolstering research and services for autistic adults.

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Neurons with low levels of ASH1L have fewer and shorter projections

Drug boosts growth of neurons deficient in autism-linked protein

by  /  25 March 2022

The neurons, which have low levels of the gene ASH1L, sprout more branches after the treatment.

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Web-based autism screening service raises a host of concerns

by  /  21 March 2022

Neurona Health, a company in San Francisco, California, backed away from part of its newly launched services after Spectrum started reporting about them.

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Autism model mice develop typical social and motor behaviors after drug treatment

by  /  9 March 2022

The drug suppresses an overactive signaling pathway implicated in tuberous sclerosis complex.

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A family of Macaques aat the Yerkes National Primate Research Center Field Station, Lawrenceville, Georgia.

Macaques’ social skills tied to variation in autism-linked genes

by  /  7 March 2022

Genetics strongly influences some aspects of the monkey’s social behavior, including tendencies to solicit grooming and sit or play alone.

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February 2022
Micrograph of neurons with excess neurons due to excess MECP2 expression.

Protein complex points to new route to Rett syndrome

by  /  18 February 2022

Mutations in a newly identified protein complex that interacts with the Rett protein also lead to a Rett-like condition in mice, researchers say.

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