Genes

A new approach for delivering gene therapy to the brain reduces nerve damage in primates and could help make gene therapies for conditions related to autism safer.

Mice missing a copy of MAGEL2 have trouble discerning between a familiar mouse and an unfamiliar one; treating them with the social hormone vasopressin reverses this deficit.

Mutations in genes that encode a histone, which gives structure to chromosomes, can lead to developmental delay and congenital anomalies.

Mutations in the autism-linked gene DNMT3A lead to the behaviors and gene-expression changes seen in different neurodevelopmental conditions.

Cells with excess UBE3A, an autism-linked protein, have atypical firing properties that can be corrected by limiting the protein’s levels, according to new research.

Sleep disruption early in life has long-lasting consequences for mice missing a copy of the autism-linked gene SHANK3.

Two unpublished studies detail improved techniques for delivering gene therapies to the brain.

Female mice missing a copy of the autism-linked gene MECP2 in a specific set of inhibitory neurons have a hard time heeding pups’ calls and herding litters.

Mutations in two genes linked to autism and intellectual disability boost the immune response and cause synapse dysfunction.

People and mice with only one working copy of the autism gene SYNGAP1 may have trouble processing sights and sounds.