Within the 16p region of the genome, the two types of variants similarly decrease neuronal gene expression — an effect that may reflect their spatial relationship.
Spectrum: Autism Research News
Rare or common, inherited or spontaneous, mutations form the core of autism risk.
The model enables the study of autism-linked genes at the earliest stages of neural development.
Psychiatric genomics promises to shed light on the genetic basis of autism, but it’s vital to include Africa in this research, Iyegbe and Okewole say.
The function of microglia and astrocytes in the brain may mediate the intersection of sex-differential biology and autism biology.
Using imaging methods to sort mouse models of autism may help identify subtypes of autistic people with similar underlying biology.
UBE3A, a key gene associated with both autism-linked conditions, can explain most — but not all — of the syndromes’ atypical neuronal properties.
Zebrafish with mutations in 10 different autism-linked genes show a range of unique and shared phenotypes.
A range of presentations at Neuroscience 2022 tie atypical social behavior to trouble discriminating between odors in the animals.