TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

October 2019
blood in a medical vial, closeup
News

Molecular signature may lead to blood test for autism

by  /  31 October 2019

Researchers have identified a distinctive pattern of gene expression in the white blood cells of young autistic boys.

0 Comments
four panels show mouse neurons showing abnormalities
News

New gene linked to autism, neuron development

by  /  30 October 2019

Mutations in the gene CSDE1 lead to a constellation of developmental delays and conditions, including autism, according to a new study.

0 Comments
Mitochondrion, coloured transmission electron micrograph (TEM). Mitochondria are a type of organelle found in the cytoplasm of eukaryotic cells. They oxidise sugars and fats to produce energy in a process called respiration. A mitochondrion has two membranes, a smooth outer membrane and a folded inner membrane. The folds of the inner membrane are called cristae, and it is here that the chemical reactions to produce energy take place. Magnification: x62,800 when printed at 10 centimetres wide.
News

Leaky mitochondria may play central role in fragile X syndrome

by  /  23 October 2019

Some traits of fragile X syndrome may be due to problems with mitochondria, the cell’s energy factories.

0 Comments
UBE3A
News

Rat model mimics communication problems in Angelman syndrome

by  /  23 October 2019

Rats missing UBE3A, the gene mutated in people with Angelman syndrome, squeak frequently but tend not to be responsive to the play and squeaks of other rats.

0 Comments
human cell
News

In-cell sequencing reveals genome’s natural geometry

by  /  23 October 2019

Researchers have developed a method for sequencing the genome of an intact single cell, revealing its spatial arrangement within the nucleus.

0 Comments
News

Researchers debut mouse model for new autism gene

by  /  23 October 2019

Mice lacking one copy of a gene called DDX3X have developmental delay and sensory, motor and behavioral problems — similar to those seen in people with a mutation in the gene.

0 Comments
Two male finches sitting on roost in cage.
News

Protein linked to autism may help birds learn songs from elders

by  /  23 October 2019

Turning down the expression of a gene linked to autism leaves zebra finches singing disorganized songs.

0 Comments
News

Gene-edited marmosets may mimic Rett syndrome traits

by  /  23 October 2019

Researchers have used the gene-editing tool CRISPR to disable the MECP2 gene in marmoset embryos. The six such marmosets created seem to recapitulate aspects of Rett syndrome.

0 Comments
Two pairs of neurons shown in red.
News

Gene editing rids mice of DNA segment linked to autism

by  /  23 October 2019

Researchers have used a new gene-editing technique to delete a segment of DNA associated with autism and schizophrenia from mouse brain cells.

0 Comments
Micrograph of brain organoid in green and red
News

Spheres of brain cells may offer crystal ball for autism’s origins

by  /  22 October 2019

Researchers have monitored the active genome in brain organoids over the course of nearly two years — and may find clues to autism’s roots.

0 Comments