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Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

News

Fragile X syndrome traits may stem from leaky mitochondria

by  /  11 September 2020
Plugging a leaky mitochondrial membrane may help fragile X neurons to mature and function more efficiently.
News
Colorful chart showing variants in chromosomes.

Scan of genomes for inherited variants lays bare new autism candidate

by  /  10 September 2020
Lowered expression of a gene called DDHD2 may increase a person's likelihood of having autism, according to a new analysis.
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Neurons in a macaque cortex express parvalbumin in red.

Virus-based method manipulates inhibitory neurons in brains

by  /  9 September 2020
A new viral tool can selectively control different types of neurons that dampen brain activity in rodents, monkeys and people.
September 2020
DNA inside of human form
News

Autism genetics, explained

by  /  3 September 2020

The more scientists dig into DNA, the more intricate its contribution to autism seems to be. Here, we unravel the complex genetics of autism.

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Zebrafish embryos with various deformities.
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CRISPR technique knocks down gene expression in animal embryos

by  /  2 September 2020

A new method that suppresses gene expression in the embryos of fish and mice may help researchers study autism genes in early development.

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August 2020
Two mice side-by-side.
News

Drug improves social behaviors, oxytocin signaling in autism mouse model

by  /  31 August 2020

Mice missing the autism gene NLGN3 have altered social behaviors and brain responses to the hormone oxytocin, both of which improve after treatment with a drug that helps regulate protein production.

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News

DNA droplets may be key to Rett syndrome, researchers say

by  /  27 August 2020

Mutations in the MECP2 gene, which are associated with autism and Rett syndrome, interfere with a cell’s ability to form droplets of DNA that silence gene expression.

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Proteins binding to RNA, illustration.
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Massive encyclopedia catalogs genome’s regulatory regions

by  /  26 August 2020

The most comprehensive catalog to date of DNA regions that modify gene expression is helping researchers uncover the role these segments play in autism.

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RNA, transcription
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Antidote to ‘poison’ DNA may treat lethal form of epilepsy

by  /  26 August 2020

An experimental drug silences a DNA segment and seems to prevent seizures and death in a condition related to autism.

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Brain images color-coded to show structural changes in autism.
News

Gene expression maps reveal origins of brain changes from autism mutations

by  /  21 August 2020

A new study pinpoints the genes and cell types that may underlie the atypical brain structure seen in people with genetic conditions linked to autism.

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Fat in bloodstream visualized as yellow balls, floating near blood cells, macro view.
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Blood lipid levels may be altered in some autistic people

by  /  10 August 2020

About 6.5 percent of autistic people in the United States also have dyslipidemia, a condition characterized by abnormal lipids levels in the blood.

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Genetic test showing repeats in DNA.
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Probe of DNA ‘repeats’ reveals new potential autism genes

by  /  10 August 2020

Repeating bits of the genome may be responsible for nearly 3 percent of the genetic architecture of autism.

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Young child on her bed looking at a book.
News

Studies unravel diversity of traits tied to chromosome 16 mutations

by  /  3 August 2020

Two new analyses help to explain why mutations to the chromosomal region 16p11.2 can lead to autism, intellectual disability or language difficulties.

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