TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

News

Mutations in chromosome 22 bring big risks, but only for some

by  /  16 July 2018
About 10 percent of people with a large mutation in chromosome 22 have autism, attention deficit hyperactivity disorder or intellectual disability.
News

New approach predicts impact of mild mutations in autism

by  /  11 July 2018
A new method enables researchers to assess the biological impact of thousands of subtle mutations.
News
a particle of gold and a protective shell nable CRISPR to traverse safely into the brain.

Gene editing via nanoparticles may treat autism syndromes

by  /  5 July 2018
A miniature particle delivers the gene-editing tool CRISPR into the brains of fragile X mice.
July 2018
News

Rat squeaks may reveal autism gene’s role in communication

by  /  2 July 2018

Rats with a mutation in CACNA1C, a gene linked to autism, make fewer happy squeaks while playing than controls do, and ignore other rats’ requests to play.

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June 2018
tangles of brightly colored RNA, DNA and enzymes
News / Toolbox

Refined versions of gene-editing tool increase its versatility

by  /  29 June 2018

Four new techniques expand the repertoire of the gene editor CRISPR.

0 Comments
Scanning electron micrograph (SEM) of Lactobacillus reuteri. Lactobacillus reuteri, a probiotic bacterium, is found in breast milk and the human gastrointestinal tract. It is also found in cattle, pigs, chickens, turkeys, mice, hamsters, gerbils, ostriches and rats. This Lactobacillus produces reuterin which suppresses pathogens in the guts.
News

Autism mutation alters balance of gut bacteria in mice

by  /  28 June 2018

Mice with a mutation in a top autism gene may have altered levels of certain gut bacteria; feeding the mice one of these bacterial species eases some of their troubles.

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Multimedia / Webinars

Journal club: Rare genetic variation in brain conditions

6 August 2018

Register for the next Spectrum journal club, featuring Andrea Ganna, who will discuss a paper exploring rare genetic variation in psychiatric conditions, including autism.

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News

Mutations in autism gene may trigger milder effects than does its loss

by  /  20 June 2018

People with mutations in SHANK3 have milder features than do those missing a chunk of DNA that includes the gene.

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Opinion / Viewpoint

Genetic testing, counseling crucial in people with developmental delay

by ,  /  19 June 2018

Referring children with developmental delay to a clinical geneticist for testing and counseling helps families and advances research.

0 Comments
Female head shape cut out of pink paper, under magnifying glass. Male head is in blue, opposite the female.
News

Autism’s sex ratio, explained

by  /  13 June 2018

More boys than girls have autism; diagnostic biases and genetic factors may explain the skewed sex ratio.

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eight brains with various sections highlighted
News

Chromosome 16 deletion miswires brain in people, mice

by  /  12 June 2018

Mice and people missing a copy of a chromosomal region called 16p11.2 show similar patterns of weak brain connections.

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News

Mice missing top autism gene have overconnected brains

by  /  11 June 2018

Mice with one inactivated copy of CHD8, a top autism gene, show an unusually high degree of synchrony in neural activity between brain regions.

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News / Toolbox

New technique scales up ability to find DNA tags in genomes

by  /  8 June 2018

A new method helps researchers map the patterns of chemical tags in large batches of cells.

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