TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

News / Toolbox
DNA twisting in black space

Two tools speed the search for mutations in whole genomes

by  /  14 September 2018
Software to identify genetic variants, along with a new synthetic human genome, could help scientists discover mutations associated with conditions such as autism.
News

Loss of large proteins underlies fragile X syndrome, study says

by  /  13 September 2018
The protein missing in fragile X syndrome, FMRP, facilitates the production of hundreds of unusually large proteins, some of which are linked to autism.
Opinion / Viewpoint
Artwork shows a flock of birds flying inside the head of a boy.

How a ‘pacemaker’ for the brain could ease autism traits

by  /  4 September 2018
Looking at the brain as a whole suggests that nudging flawed sets of neurons to collaborate better might alleviate autism traits.
August 2018
Neurons glow green in a mouse brain.
News / Toolbox

New tool triggers gene expression in select neurons in rodents

by  /  31 August 2018

Injecting a virus toting snippets of RNA into the rodent brain enables researchers to express genes in specific neuron types.

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Two scientists standing in a lab.
News / Profiles

Family ties: Sabatini brothers crack codes that may underlie autism

by  /  30 August 2018

David and Bernardo Sabatini, brothers born just a year and a half year apart, invent their way to answering big questions about autism.

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Microscopic images from the eye of a fly.
News

Mutant flies reveal key gene interactions within autism deletion

by  /  20 August 2018

The absence of several interacting genes may underlie the developmental problems seen in people missing a segment of chromosome 16.

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Multimedia / Webinars

Journal club: Rare genetic variation in brain conditions

6 August 2018

Watch the complete replay of this journal club, which featured a paper exploring rare genetic variation in psychiatric conditions, including autism.

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News

Blocking key enzyme eases memory problems, anxiety in autism mice

by  /  1 August 2018

New results implicate an enzyme called ERK in the consequences of missing a segment of chromosome 16.

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July 2018
News

Studies unveil hidden ties between epilepsy gene and autism

by  /  23 July 2018

Over the past year, HNRNPU, a gene well known for its link to epilepsy, has emerged as a new autism candidate.

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A red and blue pattern of genes.
News / Toolbox

Algorithm flags harmful mutations in single copies of genes

by  /  20 July 2018

A new tool can predict a genetic problem called ‘haploinsufficiency’ in which a mutation impairs the function of one copy of a gene.

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News

Mutations in chromosome 22 bring big risks, but only for some

by  /  16 July 2018

About 10 percent of people with a large mutation in chromosome 22 have autism, attention deficit hyperactivity disorder or intellectual disability.

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News

New approach predicts impact of mild mutations in autism

by  /  11 July 2018

A new method enables researchers to assess the biological impact of thousands of subtle mutations.

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a particle of gold and a protective shell nable CRISPR to traverse safely into the brain.
News

Gene editing via nanoparticles may treat autism syndromes

by  /  5 July 2018

A miniature particle delivers the gene-editing tool CRISPR into the brains of fragile X mice.

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