TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

News

Patterns of DNA tags mark candidate genes for autism

by  /  15 August 2019
Children with autism who carry mutations in the chromosomal region 16p11.2 or the gene CHD8 — two of the leading risk factors for autism — show distinct patterns of chemical tags on their DNA.
Features / Deep Dive
woman behind a 'curtain' of genome sequence

The problems with prenatal testing for autism

by  /  14 August 2019
As prenatal testing improves, it presents a host of thorny issues — from what to test and how to interpret the results, to what to do about them.
News / Toolbox
DNA microscopy images of cells glow green and red

New technique maps molecules through DNA ‘scope’

by  /  9 August 2019
A novel approach to microscopy reveals the sequences and spatial arrangement of DNA within cells.
July 2019
Orange patterns are created from chemical tags in brain tissue from people with autism.
News

Different forms of autism may share pattern of chemical tags on DNA

by  /  22 July 2019

Brain tissues from people with autism of unknown cause and from people with either of two genetic forms of the condition all show similar patterns of methyl groups on DNA.

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News

Gene linked to multiple forms of autism may boost risk of death from seizures

by  /  18 July 2019

Mice with extra copies of UBE3A, a gene linked to autism and related conditions, are susceptible to death from seizures.

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News

Ultrasensitive blood test may detect autism mutations in utero

by  /  18 July 2019

A blood test can accurately detect whether a fetus carries large mutations of the kind linked to autism, according to pilot-study results.

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Family together in kitchen, showing three generations
News

Majority of autism risk resides in genes, multinational study suggests

by  /  17 July 2019

About 81 percent of autism risk comes from inherited genetic factors, according to an analysis of more than 2 million children from five countries.

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group of dark furred lab mice huddling together.
News

Mutations tied to autism may alter gut function, microbiome in mice

by  /  11 July 2019

Mutations in the autism gene NLGN3 may alter the gut nervous system of mice.

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News

Family groups, researchers join forces to solve mysteries of autism gene

by  /  10 July 2019

Families of children with mutations in a gene called SYNGAP1 have spurred research into the effects of the mutations on people — and how to treat them.

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News / Toolbox

New approach aids search for genetic roots of complex conditions

by  /  5 July 2019

A new method enables researchers to test algorithms for spotting genes that contribute to a trait or condition.

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June 2019
children standing in a line, oldest to youngest
News

Timing of autism treatments may be key to their success

by  /  20 June 2019

The timing of treatment is crucial for conditions related to autism — and more so for some conditions than for others.

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Mouse neurons in a grid show differences
News

Autism mutation may disrupt brain structure by disabling mitochondria

by  /  13 June 2019

Mice that lack a segment of chromosome 22 — a mutation associated with autism — have unusually sparse connections between brain regions.

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Cells in a rat brain
News / Toolbox

CRISPR advances offer enhancements to gene-editing tool kit

by  /  7 June 2019

New versions of the DNA editor CRISPR enable scientists to turn off specific genes in rats, detect mutations in human tissue and delete segments of the genome.

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