TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

News
Close-up of child's hand on wet window

Mutations in cancer gene tied to unique autism traits

by  /  14 November 2019
Autistic people who carry mutations in a gene called PTEN have distinct behavioral and motor problems.
News / Toolbox
Chromosomes swapping DNA

CRISPR technique tracks genetic activity in real time

by  /  8 November 2019
A new method scans gene expression in live cells and could help scientists study autism genes.
News
blood in a medical vial, closeup

Molecular signature may lead to blood test for autism

by  /  31 October 2019
Researchers have identified a distinctive pattern of gene expression in the white blood cells of young autistic boys.
October 2019
four panels show mouse neurons showing abnormalities
News

New gene linked to autism, neuron development

by  /  30 October 2019

Mutations in the gene CSDE1 lead to a constellation of developmental delays and conditions, including autism, according to a new study.

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Mitochondrion, coloured transmission electron micrograph (TEM). Mitochondria are a type of organelle found in the cytoplasm of eukaryotic cells. They oxidise sugars and fats to produce energy in a process called respiration. A mitochondrion has two membranes, a smooth outer membrane and a folded inner membrane. The folds of the inner membrane are called cristae, and it is here that the chemical reactions to produce energy take place. Magnification: x62,800 when printed at 10 centimetres wide.
News

Leaky mitochondria may play central role in fragile X syndrome

by  /  23 October 2019

Some traits of fragile X syndrome may be due to problems with mitochondria, the cell’s energy factories.

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UBE3A
News

Rat model mimics communication problems in Angelman syndrome

by  /  23 October 2019

Rats missing UBE3A, the gene mutated in people with Angelman syndrome, squeak frequently but tend not to be responsive to the play and squeaks of other rats.

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human cell
News

In-cell sequencing reveals genome’s natural geometry

by  /  23 October 2019

Researchers have developed a method for sequencing the genome of an intact single cell, revealing its spatial arrangement within the nucleus.

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News

Researchers debut mouse model for new autism gene

by  /  23 October 2019

Mice lacking one copy of a gene called DDX3X have developmental delay and sensory, motor and behavioral problems — similar to those seen in people with a mutation in the gene.

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Two male finches sitting on roost in cage.
News

Protein linked to autism may help birds learn songs from elders

by  /  23 October 2019

Turning down the expression of a gene linked to autism leaves zebra finches singing disorganized songs.

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News

Gene-edited marmosets may mimic Rett syndrome traits

by  /  23 October 2019

Researchers have used the gene-editing tool CRISPR to disable the MECP2 gene in marmoset embryos. The six such marmosets created seem to recapitulate aspects of Rett syndrome.

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Two pairs of neurons shown in red.
News

Gene editing rids mice of DNA segment linked to autism

by  /  23 October 2019

Researchers have used a new gene-editing technique to delete a segment of DNA associated with autism and schizophrenia from mouse brain cells.

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Micrograph of brain organoid in green and red
News

Spheres of brain cells may offer crystal ball for autism’s origins

by  /  22 October 2019

Researchers have monitored the active genome in brain organoids over the course of nearly two years — and may find clues to autism’s roots.

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Opinion / Viewpoint

Angelman syndrome’s silent gene points way forward for autism therapies

by  /  21 October 2019

Advances in research and help from families have brought scientists to the brink of an effective therapy for Angelman syndrome.

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