TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

News
Mouse neurons in a grid show differences

Autism mutation may disrupt brain structure by disabling mitochondria

by  /  13 June 2019
Mice that lack a segment of chromosome 22 — a mutation associated with autism — have unusually sparse connections between brain regions.
News / Toolbox
Cells in a rat brain

CRISPR advances offer enhancements to gene-editing tool kit

by  /  7 June 2019
New versions of the DNA editor CRISPR enable scientists to turn off specific genes in rats, detect mutations in human tissue and delete segments of the genome.
Opinion / Viewpoint
primordial soup of ancient genes and single celled organisms

Evolution of autism genes hints at their fundamental roles in body

by  /  4 June 2019
Genes associated with autism are ancient, and mutations in them have wide-ranging effects on the body, indicating their importance.
May 2019
News

Gut microbes from autistic children may alter behavior in mice

by  /  30 May 2019

Mice colonized with gut microbes from some autistic boys show behaviors like those of the boys.

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Artists interpretation of machine learning and genes
News

Mutations between genes, long overlooked, may be key in autism

by  /  27 May 2019

Spontaneous mutations that occur between genes may be as important in autism as those within genes.

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Mouse hippocampus view
News / Toolbox

New method yields maps of gene expression in multiple dimensions

by  /  24 May 2019

An array of minute beads enables researchers to build precise maps of gene expression in the brain.

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Portrait of Mark Bear
Multimedia / Webinars

Webinar: Mark Bear discusses fragile X syndrome, from bench to bedside

14 August 2019

Register for the next Spectrum webinar, featuring Mark Bear, who will review the latest research on treatments for fragile X syndrome.

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Individual cells from the brains of autistic people show distinct gene-expression patterns, and are shown in different colors.
News

Analysis of single cells implicates set of neurons in autism

by  /  22 May 2019

A set of neurons involved in complex cognitive functions may play a central role in autism.

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Computational Modeling of BRSK2 Missense Variants
News

Matchmaking site for genes leads scientists to autism candidate

by  /  6 May 2019

A website called GeneMatcher has helped researchers identify a new gene for intellectual disability, developmental delay and autism.

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A mother taking her two children to school
News

Genetic background may alter effect of autism mutations

by  /  4 May 2019

A person’s genetic makeup can ease or worsen the effect of mutations linked to autism.

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Image of DNA made up of hundreds of tiny images in a mosaic effect.
News / Toolbox

New algorithm identifies rare mutations in single neurons

by  /  3 May 2019

A new computational method sifts true mutations from spurious ones in a single cell’s genome.

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Young girl sleeping in the bed
News

Sleep struggles in autistic people may have genetic basis

by  /  3 May 2019

Autistic children may be more likely than their unaffected siblings to carry mutations in genes linked to sleep.

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A DNA helix showing common and rare variants
News

The multiple hits theory of autism, explained

by  /  1 May 2019

Researchers are studying how a combination of genetic ‘hits’ may contribute to autism’s diversity.

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