TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

News

Analysis spotlights mutations in ‘dark’ regions of the genome

by  /  14 December 2018
Whole-genome scans of nearly 8,000 people link autism to spontaneous mutations in the stretches of DNA that regulate genes.
News
microsopy of human sperm

Study suggests Rett syndrome doesn’t always arise spontaneously

by  /  13 December 2018
Nearly one in four men who have a daughter with Rett syndrome carry mutations linked to the condition in some of their sperm.
Multimedia / Webinars

Webinar: Patricia Braga discusses stem-cell models of autism

12 December 2018
Watch the complete replay of Patricia Braga describing studies of autism involving stem cells.
December 2018
Microscopic view of spermatozoa
News

Some autism mutations go undetected, new study suggests

by  /  5 December 2018

Some mutations that contribute to autism and arise spontaneously may be mistaken for inherited mutations.

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November 2018
Large group of different lab mice: white mice, black and white mice and light brown mice, all in a cage on wood chips.
News / Toolbox

Database compares protein function across dozens of mouse strains

by  /  23 November 2018

A new resource details the protein-coding portions of the genomes of 36 popular mouse strains.

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News

Top autism gene may rewire brain by altering expression of other genes

by  /  15 November 2018

The autism gene TBR1 controls the expression of several other candidate genes that govern the architecture of the brain’s outer section.

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RNA sequences in yellow and blue.
News / Toolbox

Tool analyzes mysterious set of RNAs for clues to function

by  /  9 November 2018

A software tool finds possible functions for long RNA molecules that aren’t transcribed into proteins.

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News

Gene expression ‘barcode’ maps cells in brain tissue

by  /  7 November 2018

A new technique transforms the previous broad-brush picture of a brain region into a pointillist masterpiece of neuronal subpopulations associated with specific activities.

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News

Some autism genes may be especially vulnerable to mutations

by  /  7 November 2018

A small number of autism genes are located in fragile regions of the genome — those prone to breaking when cells copy DNA.

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Toddle boy having his head measured in a medical setting.
News

Brain organoid study firmly links autism mutations to RhoA

by  /  7 November 2018

A cellular pathway that helps neurons grow and move during fetal development may drive the changes in head size in some autistic people.

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Artistic interpretation of a neuron in the hippocampus.
News

Subset of neurons may underlie brain’s response to experience

by  /  7 November 2018

Experiences may shape the human brain by altering neurons that boost brain activity.

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Two white mice, one on a wheel, sniff noses.
News

Infection during childhood may aggravate autism risk from mutation

by  /  7 November 2018

Triggering an immune defense in newborn male mice missing a copy of TSC2, a gene linked to autism, impairs the mice’s social memory.

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News

Study links changes in blood flow to autism

by  /  7 November 2018

Mice with an autism-linked deletion in chromosome 16 show abnormalities in their blood vessels and circulation.

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