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Tag: inhibitory signaling

December 2010
News

Molecular mechanisms: Imaging technique reveals brain’s diversity

by  /  14 December 2010

A new technique called array tomography allows researchers to visualize individual synapses, the complex junctions between neurons, in the mouse brain. Researchers have also identified several markers that highlight the incredible diversity of synapse types.

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Calming neurons may ease apnea in Rett syndrome

by  /  9 December 2010

A controversial new approach that quiets the activity of certain neurons in the brain alleviates breathing difficulties in a mouse model of Rett syndrome, according to a study published 4 October in the Proceedings of the National Academy of Sciences.

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November 2010
News

Fish tale implicates language gene in autism

by  /  18 November 2010

Reducing the levels of CNTNAP2 — a gene implicated in both autism and language impairment — in zebrafish leads to a decrease in neurons that dampen signals in the brain, according to unpublished data presented Tuesday at the Society for Neuroscience annual meeting in San Diego.

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Fragile X mice have shortage of synaptic proteins

by  /  18 November 2010

The brains of young mice with fragile X syndrome show a dearth of two proteins that are important at the synapse, the junction between neurons, researchers reported Tuesday at the Society for Neuroscience annual meeting in San Diego.

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Video: Synapses are key to understanding autism

by  /  18 November 2010

Proteins that function at the synapse, the junction between neurons, have been strongly linked to autism. At the Society for Neuroscience annual meeting in San Diego, Mriganka Sur, professor of neuroscience at the Massachusetts institute of technology, explained how studying synapses is revolutionizing our understanding of autism.

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Imaging study of autism finds imbalance of signals

by  /  18 November 2010

Children with autism have an imbalance of excitation and inhibition in the brain, according to the first study to measure synchrony between brain networks using magnetoencephalography (MEG). The findings were presented Wednesday at the Society for Neuroscience annual meeting in San Diego.

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Video: Inhibitory neurons involved in Rett syndrome

by  /  17 November 2010

In a study published last week, Huda Zoghbi’s team showed that neurons that produce a neurotransmitter called gamma-aminobutyric acid, or GABA, play a crucial role in the development of Rett syndrome. Zoghbi caught up with SFARI at the Society for Neuroscience annual meeting in San Diego to discuss the study’s implications for understanding autism.

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Autism brains characterized by fewer excitatory neurons

by  /  16 November 2010

People with autism have structural differences in the temporal cortex — a brain region involved in sound and language processing — compared with controls, according to a postmortem study presented Monday at the Society for Neuroscience annual meeting in San Diego.

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Stem cell assay reveals early development of Rett neurons

by  /  16 November 2010

Researchers have developed the first stem cell system that makes it possible to study the early development of neurons from people with Rett syndrome, a rare disorder on the autism spectrum.

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Rett gene needed to stabilize synaptic strength

by  /  16 November 2010

Blocking the expression of the MeCP2 gene decreases the number of synapses, the junctions between neurons. It also prevents synapses from scaling up their activity to make up for the loss, according to unpublished data shown yesterday at the Society for Neuroscience annual meeting in San Diego.

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