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Tag: inhibitory signaling

November 2010
News

Researchers debut new mouse model for Rett syndrome

by  /  11 November 2010

A new mouse model for Rett syndrome shows that disrupting a single brain messenger can produce nearly all of the characteristic features of the syndrome, researchers report today in Nature.

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October 2010
News

Molecular mechanisms: Calming neurons have specific responses

by  /  26 October 2010

Most inhibitory neurons respond in the same way to a range of visual stimulation, but a subset of them may be tuned in to specific signals, suggest two reports published in September in Neuron.

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News

Multi-gene deletion creates model for Angelman syndrome

by  /  7 October 2010

A new mouse model of Angelman syndrome that knocks out a large stretch of a key chromosome is clarifying some of the molecular mechanisms underlying the more severe forms of the disorder.

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August 2010
News

Studies explore amygdala problems in fragile X syndrome

by  /  31 August 2010

The amygdala, a brain region that regulates fear and anxiety, shows abnormal neuronal signaling in a mouse model of fragile X syndrome, according to two studies published this summer. These are the first to explore cellular defects in the region in fragile X.

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July 2010
News

Neurexin found to have diverse partners at synapse

by  /  27 July 2010

Scientists have discovered that neurexins — proteins linked to autism — bind to a wide variety of molecules at the junction between neurons. In this complicated system, the breakdown of any one of the parts could lead to improper cell signaling, ultimately giving rise to disease.

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News

Abnormal brain growth seen in children with fragile X

by  /  7 July 2010

Children with fragile X syndrome show abnormal growth in several brain structures during the first few years of life, according to the first study to track how the disease unfolds in the brain during early development.

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March 2010
Opinion

Learning opportunities

by  /  23 March 2010

There are several short periods during development in which our brains are ‘plastic’ — meaning that neuronal connections appear and disappear depending on how much they are used. Researchers may have found a way to reopen those learning windows.

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News

Postmortem brains point to impaired inhibition in autism

by  /  4 March 2010

Researchers have found a higher density of several types of interneurons — nerve cells that connect sensory and motor neurons in the brain— in postmortem brain tissue from individuals with autism, compared with healthy controls. The findings appear in the February issue of Acta Neurologica Scandinavica.

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December 2009
News

Chemical messenger variant found in families with autism

by  /  16 December 2009

Scientists have for the first time found direct evidence that defects in the GABA receptor sometimes give rise to autism, according to research published 24 November in Molecular Psychiatry.

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November 2009
News

Loss of inhibitory neurons marks autism mouse models

by  /  24 November 2009

Autism may be the result of faulty wiring that occurs during early brain development, according to two independent studies that looked at the origins of circuit disruption.

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