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Tag: inhibitory signaling

January 2012
News

Molecular mechanisms: Autism gene tied to neuronal junctions

by  /  24 January 2012

Neurobeachin, or NBEA, an autism–associated gene, may regulate the transport of signaling molecules to neuronal branches, according to a study published 22 November in Nature Communications.

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News

Clinical research: Study suggests drug for fragile X syndrome

by  /  17 January 2012

A compound that boosts inhibitory signals in the brain could treat hyperactivity and excitability in mice that model fragile X syndrome, according to a study published 8 November in Developmental Neuroscience.

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December 2011
News / Toolbox

New system screens for drugs that alter neuronal junctions

by  /  7 December 2011

A new technique efficiently screens for compounds that enhance or inhibit the formation of synapses, the junctions between neurons, according to a study published 25 October in Nature Communications.

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November 2011
News

Mouse models point to early troubles in tuberous sclerosis

by  /  28 November 2011

The brain abnormalities characteristic of tuberous sclerosis may begin early in development and involve malfunctioning of neuronal precursors, according to studies of two different mouse models of the disorder published in October.

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Opinion / Viewpoint

A case for the importance of interneurons in autism

by ,  /  22 November 2011

The etiology of autism may be best understood as an impairment of neuronal circuits, specifically interneurons that dampen signals in the brain, says neuroscientist Gordon Fishell.  

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News / Toolbox

Mouse lines light up the brain’s off switch

by  /  16 November 2011

Researchers have engineered 20 mouse lines that allow them to manipulate genes in specific neuronal circuits. The resource, reported 22 September in Neuron, will allow researchers to better explore the role of interneurons, which dampen signals in the brain, in mouse models of autism. 

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News

Neurexins present only in select neurons

by  /  15 November 2011

Neurexins, autism-linked proteins that organize synapses, the junctions between neurons, function in only a subset of cells in the brain, according to data presented in a poster Monday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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News

Subset of Rett gene’s targets may lead to the disorder

by  /  14 November 2011

Deleting the Rett syndrome gene in a subset of neurons, instead of throughout the body, dramatically lowers the number of genes that are dysregulated in those neurons, according to results presented in a poster session Saturday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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News

Vision problems in Rett syndrome could serve as biomarker

by  /  13 November 2011

Mice missing the Rett syndrome gene MeCP2 show a gradual decline in vision, and too much inhibitory signaling in the visual cortex, according to unpublished research presented Thursday in Washington, D.C.

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News

Molecular mechanisms: MeCP2 may modify DNA structure

by  /  9 November 2011

The Rett syndrome gene MeCP2 may subtly regulate the expression of genes across the genome by altering DNA structure.

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