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Tag: inhibitory signaling

May 2011
News

Scientists probe puzzling overlap of epilepsy and autism

by  /  12 May 2011

Large studies on the epidemiology and genetics of epilepsy and autism have uncovered commonalities between the two disorders. But scientists are only beginning to untangle the biological roots of the overlap.

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April 2011
News

Specialized neurons help explore circuit defects in autism

by  /  14 April 2011

A powerful cell that dampens electrical signaling in the brain could help unravel the disrupted brain wiring seen in people with autism, according to results presented yesterday at the Wiring the Brain meeting in Ireland.

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News

Genetics: Deep sequencing reveals rare mutations

by  /  5 April 2011

Rare mutations with strong effects play a key role in autism and schizophrenia, according to a study published in February in PLoS Genetics. The study identifies rare harmful mutations in three candidate genes that are more common in individuals with one of the disorders than in controls.

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March 2011
News / Toolbox

Researchers trace wiring in the brain

by  /  30 March 2011

Researchers have mapped the architecture of a brain circuit active during vision in the cerebral cortex — a region involved in memory and planning — they reported 10 March in Nature.

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News

Molecular mechanisms: Neuroligin-4 induces synapses in a dish

by  /  23 March 2011

Neuroligin-4, a protein associated with autism, is located at synapses — the junctions between neurons — that inhibit signals in the brain, according to a study published in February in the Proceedings of the National Academy of Sciences. The protein can also single-handedly induce neurons derived from human stem cells to form synapses, according to another study in the same issue.

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January 2011
News

Genetics: Rare mutation found in gene linked to autism

by  /  31 January 2011

Researchers have identified a rare genetic variant linked to autism in DLX1, a gene that regulates the growth of neurons, they reported in December in the American Journal of Medical Genetics.

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December 2010
News

Molecular mechanisms: Imaging technique reveals brain’s diversity

by  /  14 December 2010

A new technique called array tomography allows researchers to visualize individual synapses, the complex junctions between neurons, in the mouse brain. Researchers have also identified several markers that highlight the incredible diversity of synapse types.

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News

Calming neurons may ease apnea in Rett syndrome

by  /  9 December 2010

A controversial new approach that quiets the activity of certain neurons in the brain alleviates breathing difficulties in a mouse model of Rett syndrome, according to a study published 4 October in the Proceedings of the National Academy of Sciences.

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November 2010
News

Fish tale implicates language gene in autism

by  /  18 November 2010

Reducing the levels of CNTNAP2 — a gene implicated in both autism and language impairment — in zebrafish leads to a decrease in neurons that dampen signals in the brain, according to unpublished data presented Tuesday at the Society for Neuroscience annual meeting in San Diego.

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News

Fragile X mice have shortage of synaptic proteins

by  /  18 November 2010

The brains of young mice with fragile X syndrome show a dearth of two proteins that are important at the synapse, the junction between neurons, researchers reported Tuesday at the Society for Neuroscience annual meeting in San Diego.

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