‘Outdated’ mouse model exposes key disruptions in autism brain
A mouse model based on exposure to an epilepsy drug offers a useful window into the brain circuits altered in autism.
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A mouse model based on exposure to an epilepsy drug offers a useful window into the brain circuits altered in autism.
Studies at the level of neural circuits are needed to better understand the importance of both increased and decreased connectivity between different regions in the autism brain, say John Rubenstein and Vikaas Sohal.
Understanding the function of neuronal circuits, specifically microcircuits in the prefrontal cortex and elsewhere in the brain, will play a major role in translating research findings into new autism treatments, says Vikaas Sohal.