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Tag: inhibitory signaling

February 2013
Opinion / Viewpoint

The 2003 paper proposing signaling imbalance in autism

by ,  /  26 February 2013

In 2003, John Rubenstein and Michael Merzenich first described the theory, now popular in autism, that the disorder reflects an imbalance between excitation and inhibition in the brain. Takao K. Hensch and Parizad M. Bilimoria review the paper and its impact on the field.

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Multimedia / Webinars

Vikaas Sohal on abnormal neural circuits in autism

6 March 2013

Watch the complete replay of Vikaas Sohal’s webinar on abnormal neural circuits in autism. Submit your own follow-up questions.

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News

Molecular mechanisms: Study links excess protein to autism

by  /  20 February 2013

Elevated levels of EIF4E, which plays a key role in protein synthesis, lead to autism-like behaviors and abnormal neuronal signaling in mice, according to a study published 17 January in Nature.

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News

Controversial study touts blood pressure drug for autism

by  /  18 February 2013

Bumetanide, a drug that’s long been used to treat high blood pressure, modestly improves social behaviors in children with mild forms of autism, according to the results of a small trial published in December in Translational Psychiatry.

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January 2013
News

Fragile X mice show brain-wave abnormalities during sleep

by  /  25 January 2013

Neurons in mice that model fragile X syndrome show immature, overexcitable firing patterns, particularly during sleep, according to unpublished research presented last week at the Salk Institute, Fondation IPSEN and Nature Symposium on Biological Complexity in La Jolla, California.

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News

Alzheimer’s drug aids autism mouse model

by  /  23 January 2013

Memantine, a drug used to treat Alzheimer’s disease, can reverse autism-like features in mice lacking one copy of the MEF2C gene, according to a poster presented last week at the Salk Institute, Fondation IPSEN and Nature Symposium on Biological Complexity in La Jolla, California.

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December 2012
News

Study supports flawed protein synthesis theory of autism

by  /  17 December 2012

A new study bolsters the idea that overactive protein synthesis contributes to autism. The findings, published 21 November in Nature, show that dampening a single overabundant protein, neuroligin-1, reverses both abnormal brain activity and social deficits in mice.

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October 2012
News

Valium boosts sound-touch integration in autism mouse model

by  /  15 October 2012

The anxiety drug diazepam, commonly marketed as Valium, reverses deficits in sensory integration in a mouse model of autism, according to research presented Sunday at the Society for Neuroscience annual meeting in New Orleans.

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September 2012
News / Toolbox

Human stem cells generate miniature brain regions

by  /  25 September 2012

Researchers have induced stem cells to form three-dimensional clumps of neurons that resemble miniature brains, according to a study published 31 July in Proceedings of the National Academy of Sciences.

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News / Toolbox

‘Maturation index’ predicts neurons’ developmental age

by  /  19 September 2012

Researchers have developed an index that can predict the age of developing interneurons, which inhibit signals in the brain, according to a study published 24 August in PLoS One. They then used this measurement to show that interneurons are immature in autism brains.

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