Researchers have induced stem cells to form three-dimensional clumps of neurons that resemble miniature brains, according to a study published 31 July in Proceedings of the National Academy of Sciences.
Researchers have developed an index that can predict the age of developing interneurons, which inhibit signals in the brain, according to a study published 24 August in PLoS One. They then used this measurement to show that interneurons are immature in autism brains.
A new device allows researchers to identify the precise source of an emitted brain signal measured in freely moving rats, according to a study published in the July issue of the Journal of Neurophysiology.
A compound called baclofen restores the balance between different types of brain signals and alleviates autism-like behaviors in mice, according to a study published 17 July in Translational Psychiatry. A similar drug called arbaclofen is in clinical trials as a treatment for autism and fragile X syndrome.
Researchers have homed in on the brain region thought to be responsible for the autism-like symptoms that can accompany Dravet syndrome, a rare epilepsy disorder, according to research published Wednesday in Nature.
Individuals with either of two rare forms of epilepsy have duplications or deletions that encompass genes implicated in autism and language impairment, according to a study published 27 June in Epilepsia.
An innovative technique that uses waves of light to silence brain signaling in live animals can affect subsequent neuronal signals, according to a study published 24 June in Nature Neuroscience.
Understanding the function of neuronal circuits, specifically microcircuits in the prefrontal cortex and elsewhere in the brain, will play a major role in translating research findings into new autism treatments, says Vikaas Sohal.
Mice lacking a functional copy of UBE3A, the gene missing or mutated in people with the rare developmental disorder Angelman syndrome, show less inhibitory activity than controls do, according to research published 7 June in Neuron.
An analysis of large duplications and deletions of DNA has identified new candidate genes for autism in pathways linked to the disorder. The results were published 22 May in Human Molecular Genetics.