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Tag: inhibitory signaling

January 2021
Mouse with her pup
News

Malfunctioning neurons mute sound processing in mouse model of Rett syndrome

by  /  14 January 2021

Female mice missing a copy of the autism-linked gene MECP2 in a specific set of inhibitory neurons have a hard time heeding pups’ calls and herding litters.

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neurons in mice
News

Sensory perception, cell signals disrupted in people and mice missing autism gene

by  /  13 January 2021

People and mice with only one working copy of the autism gene SYNGAP1 may have trouble processing sights and sounds.

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lab mice
News

Mice with autism-related mutations show brain signaling imbalance

by  /  4 January 2021

Mutations in POGZ, a gene strongly linked to autism, lead to a signaling imbalance in multiple brain regions in mice, according to two new studies.

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November 2020
SYNGAP1 protein between neurons.
News

Reactions from the 2020 SYNGAP1 Scientific Conference

by  /  25 November 2020

Spectrum is covering the 2020 International SYNGAP1 Scientific Conference, which took place virtually because of the coronavirus pandemic. Here we’re highlighting researchers’ reactions to noteworthy presentations.

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September 2020
Brain images showing differences in signaling in autistic and normal brains.
News

Brain signal imbalance tracks with sex and with camouflaging autism traits

by  /  17 September 2020

Autistic men show a greater imbalance between excitatory and inhibitory signaling in the brain than autistic women do, which could explain sex differences in ‘camouflaging.’

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Neurons in a macaque cortex express parvalbumin in red.
News / Toolbox

Virus-based method manipulates inhibitory neurons in brains

by  /  9 September 2020

A new viral tool can selectively control different types of neurons that dampen brain activity in rodents, monkeys and people.

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Liquid medicine being poured from bottle onto spoon.
News

Bumetanide may benefit only a subset of autistic children

by  /  3 September 2020

Contrary to previous results, the blood pressure drug did not uniformly improve autism traits in a new clinical trial.

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August 2020
Micrograph of neurons in mouse brain.
News

Inside scientists’ quest to map, modulate social circuits in autism

by  /  17 August 2020

A growing number of studies are revealing circuits that may underlie social challenges in autism — and how to fine-tune them.

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March 2020
Close-up of mouse face and whiskers.
News

Sensory sensitivity in autistic people may stem from subset of neurons

by  /  27 March 2020

Mice missing an autism gene called SHANK3 tend to be hypersensitive to touch, which may stem from underactivity of neurons that normally dampen sensory responses.

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December 2019
Mouse sniffing the air
News

Mice with autism mutation may be indifferent to social scents

by  /  5 December 2019

Neurons in mice that lack an autism gene called CNTNAP2 do not differentiate well between social and nonsocial smells — an issue that seems to stem from haphazard neuronal firing.

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