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Tag: inhibitory signaling

March 2020
Close-up of mouse face and whiskers.
News

Sensory sensitivity in autistic people may stem from subset of neurons

by  /  27 March 2020

Mice missing an autism gene called SHANK3 tend to be hypersensitive to touch, which may stem from underactivity of neurons that normally dampen sensory responses.

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December 2019
Mouse sniffing the air
News

Mice with autism mutation may be indifferent to social scents

by  /  5 December 2019

Neurons in mice that lack an autism gene called CNTNAP2 do not differentiate well between social and nonsocial smells — an issue that seems to stem from haphazard neuronal firing.

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October 2019
Group of four organoid images
News

Mass-produced organoids hint at diversity of autism

by  /  23 October 2019

Researchers have analyzed thousands of brain organoids derived from six autistic people, gaining the potential to rapidly screen drugs.

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linked hands in a pattern intertwined with DNA showing some broken parts, symbolizing mutations
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Rett syndrome’s link to autism, explained

by  /  21 October 2019

Studies of Rett syndrome hint at genes, cells and brain circuits that may be involved in autism — and may pave the way to treatments for both conditions.

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Neurons in a mouse brain are highlighted green and yellow
News

Autism gene’s loss hampers neurons’ trek through developing brain

by  /  21 October 2019

Deleting an autism gene called TRIO derails neurons’ journey to their destination.

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News

Transplanted neurons rescue social behavior but not brain circuits

by  /  20 October 2019

Injecting cells called interneurons into the brains of a mouse model of autism restores typical social behavior. But the reason for this effect is a puzzle.

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News

Signaling imbalance in mutant mice supports key autism theory

by  /  19 October 2019

Mice missing a copy of CHD8, a top autism gene, show a signaling imbalance in their brains — a finding in line with a popular hypothesis about autism’s origins.

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August 2019
News

Drugs that calm ‘touch neurons’ may ease autism traits

by  /  8 August 2019

An experimental drug that muffles the activity of neurons in the skin moderates heightened reactions to touch in six mouse models of autism.

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May 2019
News

The signaling imbalance theory of autism, explained

by  /  1 May 2019

The signaling imbalance theory holds that the brains of autistic people are hyper-excitable because of either excess neuronal activity or weak brakes on that activity.

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February 2019
Close up of mouse shows whiskers
News

Four sets of mice call popular autism theory into question

by  /  25 February 2019

An analysis of four mouse models negates certain assumptions underlying the signaling imbalance theory of autism.

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