Therapies that target the circuit could boost social activity, new findings suggest.
Spectrum: Autism Research News
Tag: inhibitory signaling
The animals recall fear more readily if a set of inhibitory neurons in the hippocampus is switched on.
Excitatory and inhibitory neurons can derive from the same cellular source in the developing human brain, a new study suggests, overturning a 20-year-old hypothesis. Tomasz Nowakowski discusses the finding’s implications for autism research.
The investigational drug arbaclofen makes autistic people’s brains respond to a visual task more like non-autistic people’s brains do.
Mice missing a copy of the gene SENP1 have atypical social behavior likely due to a signaling imbalance in the retrosplenial cortex.
An atypical thalamus may underlie not only sensory issues in autism but also difficulties with social skills, attention and memory.
Treatments that counteract the effects of an SCN2A mutation in mice increase the animals’ sociability in adulthood, according to a new unpublished study.
Jolting a bundle of nerve fibers deep in the brain restores learning and memory in mice with mutations of the autism-linked gene CDKL5.
Preliminary results suggested the treatment is no better than placebo at reducing the severity of core autism traits.
A transplant of inhibitory neurons during the second week of life prevents social difficulties and a brain signaling imbalance in mice missing a copy of FOXG1.