An analysis of genes expressed in the postmortem brains of people with autism has identified three molecular pathways linked to the disorder. The findings, published 10 December in Nature Communications, add to mounting evidence that the myriad causes of autism converge on common biological processes.
Spectrum: Autism Research News
Tag: gene networks
A rare form of autism linked to a duplication of the 15q11-13 chromosomal region shares a molecular signature with more common forms of the disorder, suggests unpublished research presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.
Analyzing the sequences of more than 20,000 people, researchers have unearthed the largest and most robust list of autism genes so far, they reported today in Nature.
A new online database called Braineac details how variations in DNA sequence shape gene expression in the human brain.
A new online resource called MouseID Genes stores information about gene interactions in the developing mouse brain and spinal cord.
Children with autism have atypical patterns of epigenetic modifications — chemical tags on DNA that influence gene expression, suggests a study published 29 May in PLOS Genetics.
Researchers have mapped interactions between hundreds of variants of proteins made from known autism risk genes, they reported 11 April in Nature Communications. The highly connected network reveals that autism genes tend to interact with each other and with many more partners than suspected.
An artificial-intelligence algorithm designed to analyze behavior has learned to recognize six genetic disorders associated with autism, according to a report published 11 February in Molecular Autism. The algorithm could be used to hone the search for autism’s genetic underpinnings.
Spontaneous and rare mutations, particularly in genes related to networks that regulate neuronal connections, contribute a small but significant proportion of the risk for schizophrenia, report two large studies published online 22 January in Nature.