Mice with microglia missing receptors for the neurotransmitter serotonin since birth have too many synapses and show social difficulties in adulthood.
Spectrum: Autism Research News
A subset of thalamic neurons support an aspect of social behavior called social recognition, according to experiments in mice.
But the alternatives, including living-brain biopsies, raise logistical and ethical questions, experts say.
Audio and motion-sensor recordings offer a remote window into a baby’s first years and make it easier for families to participate in research.
Spheres of brain cells derived from people and implanted into mouse brains recruit blood vessels and integrate with mouse neurons.
The drug mavoglurant has no effect on a brain circuit involved in social behavior in a mouse model of fragile X syndrome. That may explain its poor performance in people with the condition.
Mouse pups exposed to an immune response in the womb show autism-like behaviors and altered gene expression in brain cells called microglia.