Autism may stem from faulty feedback loops in the brain, like an air conditioning system gone awry.
Spectrum: Autism Research News
Tag: gene networks
Brian O’Roak has helped to steer some of the largest, most complex studies of autism genetics to date.
Researchers have uncovered 38 genes, including 9 autism candidates, that may fine-tune brain activity.
A new computer program predicts the effects of mutations in regions of the genome that control gene expression. Researchers can use the tool, called DeepBind, to gauge whether autism-linked mutations might block the genetic landing strips for regulatory proteins.
DNA sequences called enhancers — which boost the expression of genes from within or outside them — are enriched for genetic variants linked to autism, suggests a new study. The finding may help researchers understand how variants outside genes contribute to autism.
A new strategy sharpens the analysis of chemical tags on the DNA-protein complexes that regulate gene expression. The method may help researchers decipher how gene expression goes awry in disorders such as autism.