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Spectrum: Autism Research News

Tag: gene networks

March 2016

Questions for Richard Tsien: Taking apart autism’s machinery

by  /  22 March 2016

Autism may stem from faulty feedback loops in the brain, like an air conditioning system gone awry.

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January 2016

Rising star: Brian O’Roak brings ‘A’ game to autism genetics

by  /  21 January 2016

Brian O’Roak has helped to steer some of the largest, most complex studies of autism genetics to date.

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Some autism genes may act as control knobs for brain activity

by  /  4 January 2016

Researchers have uncovered 38 genes, including 9 autism candidates, that may fine-tune brain activity.

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December 2015

Notable papers of 2015

by  /  22 December 2015

Our top 10 papers for this year, based on input from autism researchers, capture the full spectrum of findings — from molecular biology to large-scale epidemiology.

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October 2015

Expression of mouse genes can vary by sex, strain

by  /  18 October 2015

Patterns of gene expression in the brain vary dramatically between male and female mice — a finding that highlights the hazards of using only male mice to study complex disorders.

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New methods tighten ​net​ around autism genes

by  /  9 October 2015

Autism researchers are sharpening their statistical tools to make sense of the growing pool of autism genes.

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Dispatches from ASHG 2015

by  /  9 October 2015

These short reports from our reporter, Jessica Wright, give you the inside scoop on developments at the 2015 American Society of Human Genetics Annual Meeting.

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August 2015

Software forecasts effects of mysterious mutations

by  /  26 August 2015

A new computer program predicts the effects of mutations in regions of the genome that control gene expression. Researchers can use the tool, called DeepBind, to gauge whether autism-linked mutations might block the genetic landing strips for regulatory proteins.

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Control centers for genes rife with autism-linked DNA blips

by  /  3 August 2015

DNA sequences called enhancers — which boost the expression of genes from within or outside them — are enriched for genetic variants linked to autism, suggests a new study. The finding may help researchers understand how variants outside genes contribute to autism.

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July 2015

Method improves analysis of chemical tags that control genes

by  /  8 July 2015

A new strategy sharpens the analysis of chemical tags on the DNA-protein complexes that regulate gene expression. The method may help researchers decipher how gene expression goes awry in disorders such as autism.

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