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Spectrum: Autism Research News

Tag: gene networks

February 2012

Human neuron model tests function of autism-linked genes

by  /  16 February 2012

Simulating neuronal development in culture with cells derived from human brain tissue offers a new way to study the function of autism-linked genes, according to research published in the February issue of Molecular Psychiatry.

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Diverse data networks point to driving force in diseases

by  /  2 February 2012

A mathematical approach called ‘NEW biology,’ or network-enabled wisdom biology, aims to solve one of the biggest problems in disease research: isolating the key factors that drive diseases from a glut of information.

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January 2012

Brain atlas maps gene expression across development

by  /  4 January 2012

Researchers have charted the expression of more than 15,000 brain genes across 15 stages of development, spanning from 4 weeks post-conception to more than 60 years of age, they reported 27 October in Nature.

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December 2011

The year in review

by  /  23 December 2011

The ten notable papers picked by SFARI staff describe superb contributions that span the breadth of autism research from molecules to behavior. But we recognize that ten other articles might have been selected without loss of enthusiasm or excitement.

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Yellow and orange molecular model of the secondary structure of interleukin-10, a small protein known as a cytokine that plays an important regulatory role in the body's immune system.

Studies of early development reveal immune link to autism

by  /  15 December 2011

The molecular soldiers of the immune system may contribute to many cases of autism, according to a diverse array of studies published in the past few months.

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Study charts epigenetic landscape of autism brains

by  /  5 December 2011

In the brains of some individuals with autism, chemical changes to histones, proteins entwined with DNA, tend to show up near genes linked to the disorder, according to a study published 7 November in the Archives of General Psychiatry.

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November 2011

Researchers map microRNAs in autism brains

by  /  17 November 2011

Researchers have charted the expression of tiny pieces of RNA in postmortem brain tissue from people with autism, according to unpublished research presented Tuesday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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New approach mines multiple sources to link genes to disease

by  /  14 November 2011

Researchers have developed a computational technique that allows them to simultaneously use multiple types of information — including gene expression, ratings and associations — to identify candidate genes for a disorder. The unpublished results were presented Sunday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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Subset of Rett gene’s targets may lead to the disorder

by  /  14 November 2011

Deleting the Rett syndrome gene in a subset of neurons, instead of throughout the body, dramatically lowers the number of genes that are dysregulated in those neurons, according to results presented in a poster session Saturday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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‘Outlier’ genes expressed differently in people with autism

by  /  13 November 2011

Individuals who have autism show distinct patterns of gene expression in neurological pathways compared with their unaffected siblings, according to unpublished work presented Saturday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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