Simulating neuronal development in culture with cells derived from human brain tissue offers a new way to study the function of autism-linked genes, according to research published in the February issue of Molecular Psychiatry.
Spectrum: Autism Research News
Tag: gene networks
A mathematical approach called ‘NEW biology,’ or network-enabled wisdom biology, aims to solve one of the biggest problems in disease research: isolating the key factors that drive diseases from a glut of information.
Researchers have charted the expression of more than 15,000 brain genes across 15 stages of development, spanning from 4 weeks post-conception to more than 60 years of age, they reported 27 October in Nature.
The molecular soldiers of the immune system may contribute to many cases of autism, according to a diverse array of studies published in the past few months.
In the brains of some individuals with autism, chemical changes to histones, proteins entwined with DNA, tend to show up near genes linked to the disorder, according to a study published 7 November in the Archives of General Psychiatry.
Researchers have developed a computational technique that allows them to simultaneously use multiple types of information — including gene expression, ratings and associations — to identify candidate genes for a disorder. The unpublished results were presented Sunday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.
Deleting the Rett syndrome gene in a subset of neurons, instead of throughout the body, dramatically lowers the number of genes that are dysregulated in those neurons, according to results presented in a poster session Saturday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.
Individuals who have autism show distinct patterns of gene expression in neurological pathways compared with their unaffected siblings, according to unpublished work presented Saturday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.