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Tag: epigenetics

October 2012
News

Genetics: RNA improvisations altered in autism

by  /  9 October 2012

RNA editing, which creates multiple forms of a protein, is common among proteins involved in neuronal signaling, and may be abnormal in people with autism, according to a study published 7 August in Molecular Psychiatry.

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August 2012
Opinion / Viewpoint

Genes and environment are two-way street in autism risk

by  /  21 August 2012

Genes and the environment each influence the role of the other in determining the risk of developing autism. Genetics can determine how susceptible one is to the environment, and environmental factors can influence gene expression and introduce mutations, says immunologist Janine LaSalle.

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Opinion

Missed patterns

by  /  14 August 2012

The assumption in some published overviews of autism tends to be that all of the problems relevant to the disorder can be found at synapses, the junctions between neurons. But it’s difficult not to notice the striking number of chromatin-associated genes that have emerged as candidate risk factors over the past few months.

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July 2012
Opinion

Twin differences

by  /  31 July 2012

Identical twins are born with significant differences in the chemical modifications to their DNA, suggesting that the uterine environment can profoundly influence development and risk for disease.

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June 2012
News

Lack of DNA modification creates hotspots for mutations

by  /  28 June 2012

The absence of a chemical alteration called methylation on some stretches of DNA makes them especially prone to mutations, according to a paper published in PLoS Genetics in May.

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Opinion

Epigenetic age

by  /  22 June 2012

Normal aging triggers dramatic changes to the epigenome, the set of chemical tags that turn genes on and off, according to a new study.

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May 2012
News

Long-term project charts methylation patterns in pregnancy

by  /  18 May 2012

By studying pregnant women who already have a child with autism, researchers hope to understand how epigenetic changes — those that affect gene expression but don’t directly alter DNA — during pregnancy influences risk of the disorder.

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February 2012
News

Cognition and behavior: Contaminant acts with autism gene

by  /  28 February 2012

A commonly used flame retardant may lead to deficits in sociability, learning and memory in healthy female mice and those that model Rett syndrome, according to a study published 15 February in Human Molecular Genetics. The effects are different in Rett syndrome models compared with healthy mice, suggesting gene-environment interactions.

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News / Toolbox

Study charts methylation patterns in developing brain

by  /  22 February 2012

Researchers have charted patterns of DNA methylation — a chemical alteration to DNA that modifies gene expression — in the planning center of the brain from before birth to old age. The results were published 10 February in The American Journal of Human Genetics.

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News / Toolbox

Researchers chart 3D structure of fruit fly chromosomes

by  /  15 February 2012

A new study reveals the three-dimensional structure of fruit fly chromosomes, which groups together active and inactive genes. The results were published 3 February in Cell.

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