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Tag: epigenetics

January 2021
DNMT3A protein attaches a methyl group tag onto the DNA base cytosine.
News

Autism-related conditions converge on same loss of DNA tags

by  /  20 January 2021

Mutations in the autism-linked gene DNMT3A lead to the behaviors and gene-expression changes seen in different neurodevelopmental conditions.

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human and mouse cells.
News / Toolbox

Atlas pair profiles fetal gene expression, regulation in single cells

by  /  7 January 2021

A pair of new atlases that profile millions of cells across 15 organs offer an unparalleled look at gene activity during fetal development.

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October 2020
News

Integrating molecular data may reveal subgroups of autism

by  /  30 October 2020

An analysis of four molecular datasets shows a distinct signature, including changes in gene expression and chemical DNA modifications, in some autism brains.

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Ralf Schmid, the research director in Neurodevelopmental diseases at the Gene Therapy Program Orphan Disease Center, loads replicated mouse dna into wells in the gel before applying electric current to test the viability of the dna.
Features / Deep Dive

A quest for Quincy: Gene therapies come of age for some forms of autism

by ,  /  14 October 2020

A gene therapy for Angelman syndrome stands at the forefront of efforts to treat autism-linked conditions that stem from single genes.

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August 2020
Proteins binding to RNA, illustration.
News / Toolbox

Massive encyclopedia catalogs genome’s regulatory regions

by  /  26 August 2020

The most comprehensive catalog to date of DNA regions that modify gene expression is helping researchers uncover the role these segments play in autism.

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January 2020
stork flying with an alarm clock, dice and a crescent moon
News

The link between parental age and autism, explained

by  /  28 January 2020

Older men and women are more likely than young ones to have a child with autism, but this connection is not straightforward.

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Teenage girl with headache
News

Autistic people have increased incidence of neurological problems

by  /  23 January 2020

People with autism have more brain-related health problems, such as headaches and epilepsy, than typical people do.

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October 2019
black and blue striped dress on pregnant woman shows DNA helix
Opinion / Q&A

Rare access to fetal tissue yields valuable insights into autism

by  /  15 October 2019

Molecular biologist Jonathan Mill is probing gene expression’s role in autism in uncharted territory — the fetal human brain.

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News

Study finds unexpected role for top autism gene

by  /  14 October 2019

SETD5, a leading candidate for autism risk, may control thousands of genes by modifying a protein involved in packaging DNA.

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September 2019
Scientist Annie Ciernia runs in the forest, wearing lab coat and carrying a stack of papers that are also flying along behind her
Opinion / Q&A

Beyond the bench: A conversation with Annie Ciernia

by  /  10 September 2019

Annie Ciernia describes the greenhouse origins of her scientific career and why a unicorn makes a good lab mascot.

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