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Tag: epigenetics

February 2015

Maternal infection exacerbates genes’ effect on autism

by  /  23 February 2015

Children with too many or too few copies of certain genes are more likely to have autism, as are children born to women who battled a severe infection while pregnant. These seemingly disparate risk factors may work together to worsen autism symptoms.

January 2015
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Method charts lifetime expression of DNA in brain

by  /  21 January 2015

A new database that maps changes in gene expression in the prefrontal cortex shows that autism-linked genes are expressed differently than other genes through six stages of life.

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Technique reveals convoluted curves of chromosomes

by  /  14 January 2015

A new method is faster and more accurate than previous methods at revealing the complex folds that help to fit nearly six feet of DNA into the tiny nucleus of a cell.

December 2014
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Genetic encyclopedia highlights human-mouse differences

by  /  24 December 2014

Although mice and humans have many genes in common, a new catalog highlights significant differences in how these genes are regulated. This resource, dubbed mouse ENCODE, clarifies the extent to which mice can accurately model complex human diseases such as autism.

November 2014

Mutation boosts paternal age’s autism-like effects in mice

by  /  19 November 2014

Mice born to older males with mutations in PAX6 — a gene involved in brain development — vocalize less than those with younger dads. The unpublished findings, presented today at the 2014 Society for Neuroscience annual meeting in Washington, D.C., suggest how genes and paternal age can work together to trigger symptoms.

September 2014

New clues connect altered patterns of DNA tags to autism

by  /  16 September 2014

Methyl tags on DNA are distributed differently in postmortem brains from people with autism than in control brains, and mouse pups can inherit altered methylation from their older fathers, report two new studies.

August 2014

Age alters patterns of chemical tags on sperm DNA

by  /  18 August 2014

The configuration of methyl groups that modify DNA in sperm change as men get older. These alterations may help explain why children of older fathers are at increased risk for neuropsychiatric disorders such as autism.

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July 2014

Molecular mechanisms: Patterns of DNA tags altered in autism

by  /  8 July 2014

Children with autism have atypical patterns of epigenetic modifications — chemical tags on DNA that influence gene expression, suggests a study published 29 May in PLOS Genetics.

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Genetics: Changes in gene expression linked to father’s age

by  /  1 July 2014

Mice with older fathers have different gene expression patterns in their brains than do mice with younger fathers, reports a study published 23 March in Molecular Autism. Many of the differences involve genes linked to autism.

May 2014

Genetics: Extra copy of Rett gene blocks neuron growth

by  /  20 May 2014

Having one too many copies of MeCP2, the Rett syndrome gene, may block the growth of neuronal branches by interfering with the production of small pieces of RNA, according to a study published 10 March in Developmental Cell.