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Tag: epigenetics

February 2012
Opinion / Viewpoint

Insights for autism from attention deficit hyperactivity disorder

by  /  7 February 2012

Autism and attention deficit hyperactivity disorder show genetic and neurobiological overlap, which may provide clues to the origin of both disorders, says Joel Nigg.

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January 2012
Opinion / Viewpoint

The value of blood cells in autism research

by  /  10 January 2012

Blood from individuals with autism could help researchers identify biomarkers to diagnose the disorder and learn more about related symptoms, such as gastrointestinal complaints, says molecular biologist Valerie Hu.

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December 2011
News

Molecular mechanisms: Master regulator altered in autism

by  /  16 December 2011

SP1, a protein that regulates the expression of several autism candidate genes, could increase risk of the disorder by simultaneously altering the expression of a number of the genes, according to a study published 24 October in Biological Psychiatry.

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News

Molecular mechanisms: Protein linked to autism-like behavior

by  /  9 December 2011

HMGN1, a protein that regulates gene expression, leads to social deficits and hyperactivity when expressed at elevated levels in mice, according to a study published 9 December in the Journal of Biological Chemistry. This effect may result from HMGN1 dampening MeCP2 expression, the study suggests.

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News

Study charts epigenetic landscape of autism brains

by  /  5 December 2011

In the brains of some individuals with autism, chemical changes to histones, proteins entwined with DNA, tend to show up near genes linked to the disorder, according to a study published 7 November in the Archives of General Psychiatry.

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November 2011
News / Toolbox

Stem cell lines shed light on autism-related disorders

by  /  23 November 2011

Researchers have derived neurons from stem cells to investigate mutations that lead to Rett and fragile X syndromes.

2 Comments
News

Schizophrenia deletion could rouse silent mutations

by  /  14 November 2011

Deletion of 22q11, a schizophrenia-associated chromosomal region, may activate previously silent mutations, according to unpublished work presented Sunday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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News

Video: A landscape view of DNA modifications

by  /  14 November 2011

In a video interview at the 2011 Society for Neuroscience annual meeting in Washington, D.C., Janine LaSalle makes a case for the importance of the methylome in autism research.

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News

Molecular mechanisms: MeCP2 may modify DNA structure

by  /  9 November 2011

The Rett syndrome gene MeCP2 may subtly regulate the expression of genes across the genome by altering DNA structure.

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October 2011
News

Genetics: Large analysis pins down schizophrenia regions

by  /  26 October 2011

A massive association study links five new genetic regions to schizophrenia and implicates MIR137, a regulatory RNA that plays a role in neuron development, in the disorder.

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