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Spectrum: Autism Research News

Tag: brain size

May 2012

Autism gene PTEN plays vital role in neural stem cells

by  /  31 May 2012

Knocking out an autism-linked gene called PTEN only in neural stem cells of the hippocampus, a brain region central to learning and memory, throws the development of new neurons off course in adult mice, according to research published last month in the Journal of Neuroscience.

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Fish study links chromosome 16 genes to head size

by  /  17 May 2012

By creating genetically engineered fish, two independent groups have identified genes in an autism hotspot on chromosome 16 that influence head size and brain development. 

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Cognition and behavior: Autism, antisocial brains differ

by  /  1 May 2012

Autism and antisocial disorder are separate conditions, with distinct differences in underlying brain structure, according to a neuroimaging study of the general population. The results were published 4 April in The Journal of Neuroscience.

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April 2012

Clinical research: Study suggests four autism subgroups

by  /  25 April 2012

Individuals with autism may belong to one of four groups with discrete sets of symptoms, the most distinct of which includes immune system abnormalities accompanied by sleep problems and sensory sensitivity. The results were published in the April issue of Autism Research.

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Gene expression altered in postmortem autism brains

by  /  23 April 2012

Postmortem brain tissue from people with autism shows differences in the expression of genes involved in a number of molecular pathways, including those that control cortical patterning, programmed cell death and differentiation, according to research published last month in PLoS Genetics.

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Giant imaging study identifies genes that govern brain size

by  /  19 April 2012

The largest brain imaging study ever performed has identified candidate genes that influence brain size and general intelligence, according to research published 15 April in Nature Genetics.

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Cognition and behavior: Corpus callosum smaller in autism

by  /  4 April 2012

Children with autism have a smaller corpus callosum, a bundle of nerve fibers that connects the two hemispheres of the brain, compared with controls, and this difference persists over two years of development, according to a study published 18 February in the Journal of Autism and Developmental Disorders.

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March 2012

Cognition and behavior: Brain changes tied to autism severity

by  /  16 March 2012

Adults with autism have regional differences in brain volume in areas that play a role in social behavior and communication compared with controls, according to a large study published in the February issue of Archives of General Psychiatry. The differences correlate with the severity of autism symptoms, the study also shows.

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Autism mutations lead to scores of symptoms in rodents

by  /  14 March 2012

Mutations in more than 100 autism-associated genes lead to shared neurobiological deficits in mice, including alterations in the shape of their brains and changes to the electrical properties of neurons, according to a study published 20 February in Molecular Autism.

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RAS pathway, a potentially unifying theory of autism

by  /  13 March 2012

Dysregulation of the intracellular signaling pathway RAS, a risk factor for idiopathic autism, may provide a unifying theory of the disorder. Although this is not an altogether new hypothesis, several new findings have strengthened the evidence for it considerably.

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