The largest brain imaging study ever performed has identified candidate genes that influence brain size and general intelligence, according to research published 15 April in Nature Genetics.
Spectrum: Autism Research News
Tag: brain size
Children with autism have a smaller corpus callosum, a bundle of nerve fibers that connects the two hemispheres of the brain, compared with controls, and this difference persists over two years of development, according to a study published 18 February in the Journal of Autism and Developmental Disorders.
Adults with autism have regional differences in brain volume in areas that play a role in social behavior and communication compared with controls, according to a large study published in the February issue of Archives of General Psychiatry. The differences correlate with the severity of autism symptoms, the study also shows.
Mutations in more than 100 autism-associated genes lead to shared neurobiological deficits in mice, including alterations in the shape of their brains and changes to the electrical properties of neurons, according to a study published 20 February in Molecular Autism.
Dysregulation of the intracellular signaling pathway RAS, a risk factor for idiopathic autism, may provide a unifying theory of the disorder. Although this is not an altogether new hypothesis, several new findings have strengthened the evidence for it considerably.
The brains of men and women with Asperger syndrome are more similar than are those of male and female controls, according to a study published in the January issue of the American Journal of Neuroradiology. The results lend support to the ‘extreme male brain’ theory of autism, the researchers say.
Autism and attention deficit hyperactivity disorder show genetic and neurobiological overlap, which may provide clues to the origin of both disorders, says Joel Nigg.
The results of two new studies support recommendations against the use of brain scans to diagnose autism.
Scanning children’s brains while they sleep is a viable alternative to sedation for infants and toddlers across the entire autism spectrum, according to a study published in the January issue of the Archives of General Psychiatry.
A mouse model of Rett syndrome that mimics a mutation seen in people shows many features of the disorder, such as hand clasping, according to a study published 27 November in Nature Neuroscience.