The X chromosome holds stronger-than-expected genetic sway over the structure of several brain regions. The genes that may underlie this oversized influence have ties to autism.

Inhibiting a protein that helps cells move or change shape prevents atypical neuronal migration in 3D clusters of brain cells carrying autism-linked genetic variants.

An autism-linked mutation could make the brain grow unusually large by prompting cells to express a chemical signal better known for its connection to cancer.

A genetic therapy and an existing drug both restore typical brain size in mice missing DYRK1A, a top autism candidate gene, in the cerebral cortex, a new study shows. The animals typically have smaller brains than controls.

Deleting the autism-linked gene CHD8 from specific cells in the cerebellum, a brain region important for movement, leads to motor deficits but does not alter social behaviors in mice.

A growing body of evidence shows that brain cells called oligodendrocytes may play a larger role in autism than previously thought.

Mutations in autism-linked genes lead to a variety of changes in brain activity, sensory perception and sleep-wake cycles in zebrafish.

A screening technique tests how inactivated genes affect spheres of cultured brain cells; it could shed light on autism-linked mutations.