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Spectrum: Autism Research News

Tag: hippocampus

July 2012

Expression data links gene candidates to autism

by  /  11 July 2012

Identifying genetic variants that affect the expression of other genes can enhance traditional gene association analyses and highlight candidate risk factors for autism, according to a study published 16 May in Molecular Autism.

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June 2012

SHANK2 mouse models show opposite brain signaling

by  /  25 June 2012

Two new strains of mice carrying different mutations in the SHANK2 gene show similar autism-like behaviors but opposing effects on brain signaling, according to two independent studies published 14 June in Nature.

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May 2012

Autism gene PTEN plays vital role in neural stem cells

by  /  31 May 2012

Knocking out an autism-linked gene called PTEN only in neural stem cells of the hippocampus, a brain region central to learning and memory, throws the development of new neurons off course in adult mice, according to research published last month in the Journal of Neuroscience.

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Molecular mechanisms: Mutant mice show signs of autism

by  /  25 May 2012

Mice that are unable to produce a carbohydrate molecule that regulates cell growth show behaviors that resemble the core deficits of autism, according to a study published 27 March in the Proceedings of the National Academy of Sciences.

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Complex case

by  /  4 May 2012

Multiple levels of complexity make it challenging to develop drugs to treat autism.

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April 2012

Molecular mechanisms: Stress pathway dysregulated in autism

by  /  27 April 2012

Two studies report abnormalities in the system that mediates the body’s response to stress in two mouse models of autism-related diseases: Angelman syndrome and Rett syndrome. The results were published in the April issue of Human Molecular Genetics.

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Giant imaging study identifies genes that govern brain size

by  /  19 April 2012

The largest brain imaging study ever performed has identified candidate genes that influence brain size and general intelligence, according to research published 15 April in Nature Genetics.

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Genetics: Rare, common autism variants may function together

by  /  3 April 2012

Researchers have mapped networks of genes expressed at the same time and place in the brain and shown that rare and common autism-linked mutations are likely to function in the same pathways. The results were published 8 March in PLoS Genetics.

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March 2012

Molecular mechanisms: Extra MeCP2 affects brain signaling

by  /  30 March 2012

Mice with an extra copy of MeCP2, the Rett syndrome gene, have impaired signaling between neurons in the hippocampus, a brain region that plays an important role in memory, according to a study published 29 February in The Journal of Neuroscience.

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January 2012

Cognition and behavior: Brain scans yield few signs of autism

by  /  31 January 2012

The results of two new studies support recommendations against the use of brain scans to diagnose autism.

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