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Spectrum: Autism Research News

Tag: hippocampus

December 2010

Molecular mechanisms: Lithium treats adult fragile X symptoms

by  /  8 December 2010

Treating adult mice with lithium restores the ability of neurons in fragile X mice to fine-tune their signaling, according to a study published online in November in Brain Research.

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Molecular mechanisms: New pathway for fragile X treatment

by  /  2 December 2010

Inhibiting the ERK1/2 pathway — which regulates the synthesis of other proteins — can rescue some of the effects of fragile X syndrome, according to a study published 17 November in the Journal of Neuroscience. The ERK pathway could provide a novel target for fragile X therapies.

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November 2010

Modeling captures mouse habitat’s effect on neurons

by  /  19 November 2010

Computerized three-dimensional modeling shows nerve cell abnormalities in the hippocampus of fragile X mice — and suggests the importance of raising experimental mice in more natural habitats, according to a poster presented Wednesday at the Society for Neuroscience annual meeting in San Diego.

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Fragile X mice have shortage of synaptic proteins

by  /  18 November 2010

The brains of young mice with fragile X syndrome show a dearth of two proteins that are important at the synapse, the junction between neurons, researchers reported Tuesday at the Society for Neuroscience annual meeting in San Diego.

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Allen Institute charts gene expression in brain development

by  /  17 November 2010

The Allen Institute for Brain Science has released whole-genome expression data from one-and-a-half adult human brains, and is gathering information from samples at different stages of development, from four weeks after conception to adulthood. The data were described at poster sessions Saturday and Tuesday at the Society for Neuroscience annual meeting in San Diego.

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Autism brains characterized by fewer excitatory neurons

by  /  16 November 2010

People with autism have structural differences in the temporal cortex — a brain region involved in sound and language processing — compared with controls, according to a postmortem study presented Monday at the Society for Neuroscience annual meeting in San Diego.

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Mouse models gene-environment interactions in autism

by  /  15 November 2010

The gene-environment interactions that are thought to contribute to many cases of autism can now be explored in a mouse model, according to a poster presented Sunday at the Society for Neuroscience annual meeting in San Diego.

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Molecular mechanisms: Maternal infection linked to schizophrenia in mice

by  /  9 November 2010

Infection early in pregnancy is more harmful to the fetus than at later stages, triggering brain and behavioral changes in the offspring similar to those seen in people with schizophrenia, according to two mouse studies published in October. A third study suggests that exercise can mitigate some of these effects.

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Mutant mouse pins PSD-95 in Williams syndrome

by  /  2 November 2010

Mice missing a large protein at the junction between neurons show motor impairments, anxiety and increased social behaviors, according to a study in the American Journal of Psychiatry. The protein, postsynaptic density-95 or PSD-95, is part of a key molecular bridge connecting other proteins linked to autism.

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September 2010

Fragile X protein tied to snags in stem cell development

by  /  13 September 2010

The protein missing in fragile X syndrome is necessary for the proper development of neural stem cells — self-renewing cells that can differentiate into more specialized types, including neurons — according to a paper published in the August issue of Human Molecular Genetics.

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