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Spectrum: Autism Research News

Tag: hippocampus

March 2023
Research image of cultured neurons.

Cannabis compound rebalances signaling to quell seizures in mice

by  /  22 March 2023

Cannabidiol (CBD) blocks the action of a molecule that drives an overexcitability feedback loop in a rodent model of epilepsy.

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January 2023
Research image showing neuronal activity in mice exposed to high-frequency sounds.

Missing mechanism helps solve fragile X protein mystery

by  /  24 January 2023

Cells from people with fragile X syndrome overproduce — but don’t accumulate — proteins. New work suggests that excessive protein breakdown may account for this discrepancy, and explain some of the syndrome’s traits.

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November 2022
An older woman with gray hair sits on a couch and speaks with a clinician.

Brain’s memory center flags autistic adults at risk for cognitive decline

by  /  17 November 2022

Brain scans of the hippocampus reveal autistic people who are at increased risk of cognitive problems as they get older.

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A white mouse sits on a nest against a blue background.

Mouse models help sniff out olfactory differences in autism

by  /  16 November 2022

A range of presentations at Neuroscience 2022 tie atypical social behavior to trouble discriminating between odors in the animals.

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July 2022

Plethora of protein-making machines in neurons may underlie fragile X

by  /  21 July 2022

An overabundance of ribosomes drives an imbalance of proteins produced from long and short genetic transcripts in a mouse model of fragile X syndrome.

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April 2022

Faulty inhibition foils long-term memory in Rett mice

by  /  11 April 2022

The animals recall fear more readily if a set of inhibitory neurons in the hippocampus is switched on.

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January 2022
Micrograph showing distinct RNA species found in CA1 hippocampal neuronal cell bodies (yellow) and dendrites (red) undergoing compartmentalized RNA regulation.

Location prompts fragile X protein to flip its function

by  /  31 January 2022

The protein, FMRP, shapes cell signaling near synapses but switches to regulate genes in the cell body, according to new research.

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December 2021

Myelin loss may explain how autism-linked DNA deletion affects cognition

by  /  8 December 2021

Deleting a copy of the gene TBX1 depletes the fatty myelin insulation that surrounds neurons and reduces cognitive speed in mice.

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November 2021
UBE3A expression in mouse brain slices, shown in green.

One-shot gene therapy for Angelman syndrome shows promise in mice

by  /  29 November 2021

A potential new gene therapy delivered via a single injection mimics ratios of proteins normally found in cells.

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Fragile X theory falters on amygdala test

by  /  10 November 2021

Activating certain receptors in the amygdala — a treatment that runs counter to a leading theory of what causes the condition — can reverse some traits in rats.

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