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Spectrum: Autism Research News

Tag: hippocampus

September 2011

Brain activity triggers widespread epigenetic changes

by  /  26 September 2011

Methylation marks were thought to be permanent features of the genome, but a new study challenges that idea.

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Cognition and behavior: Probiotics alleviate anxiety in mice

by  /  20 September 2011

Probiotic bacteria alleviate stress in healthy mice and modify the expression of receptors for a chemical messenger that inhibits signaling in the brain.

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August 2011

Molecular mechanisms: MeCP2 regulated by chemical switch

by  /  17 August 2011

MeCP2, the protein missing in people with Rett syndrome, enhances learning and memory by binding to key genes and either activating or inhibiting their expression, according to a study published 17 July in Nature Neuroscience. Adding a phosphate to the protein in response to neuronal activity releases MeCP2 from these genes, the study found.

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July 2011

Ambitious venture aims to create a mouse for every gene

by  /  7 July 2011

A multi-site collaborative venture between the U.S., Canada and Europe has created nearly 17,000 mouse embryonic stem cell lines, each lacking one of the genes in the mouse genome.

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May 2011

Rett protein alters visual circuits in mice

by  /  23 May 2011

MeCP2, the protein that’s missing or mutated in Rett syndrome, is crucial for remodeling neural circuits in response to vision, according to a study published in April in Neuron.

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April 2011

Specialized neurons help explore circuit defects in autism

by  /  14 April 2011

A powerful cell that dampens electrical signaling in the brain could help unravel the disrupted brain wiring seen in people with autism, according to results presented yesterday at the Wiring the Brain meeting in Ireland.

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March 2011

New SHANK3 mouse shows autism-like features

by  /  21 March 2011

Researchers have created a mouse carrying a deletion in SHANK3, an autism candidate gene, they reported yesterday in Nature. This is the second model of SHANK3 mutations but shows markedly more behavioral and brain defects compared with the first.

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February 2011

Molecular mechanisms: Mice model milder form of fragile X

by  /  16 February 2011

A partial mutation that leads to a milder form of fragile X syndrome causes deficits in learning and memory in mice, and alters the connections between their neurons, according to a study published in January in Neurobiology of Disease.

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Window into brain reveals real-time growth of neurons

by  /  15 February 2011

A new technique allows researchers to watch the long-term effects of disease on the brain, according to a study published in the February Nature Medicine. The approach could help scientists study changes in the brain that result from neurological disorders such as autism.

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January 2011

Researchers debut autism mouse model lacking SHANK3

by  /  17 January 2011

Scientists have created mice that carry mutations in SHANK3, one of the strongest candidate genes for autism. The animals have behavioral and neurobiological features reminiscent of autism, researchers reported 17 December in Molecular Autism.

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