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Spectrum: Autism Research News

Tag: hippocampus

May 2012

Autism gene PTEN plays vital role in neural stem cells

by  /  31 May 2012

Knocking out an autism-linked gene called PTEN only in neural stem cells of the hippocampus, a brain region central to learning and memory, throws the development of new neurons off course in adult mice, according to research published last month in the Journal of Neuroscience.


Molecular mechanisms: Mutant mice show signs of autism

by  /  25 May 2012

Mice that are unable to produce a carbohydrate molecule that regulates cell growth show behaviors that resemble the core deficits of autism, according to a study published 27 March in the Proceedings of the National Academy of Sciences.


Complex case

by  /  4 May 2012

Multiple levels of complexity make it challenging to develop drugs to treat autism.

April 2012

Molecular mechanisms: Stress pathway dysregulated in autism

by  /  27 April 2012

Two studies report abnormalities in the system that mediates the body’s response to stress in two mouse models of autism-related diseases: Angelman syndrome and Rett syndrome. The results were published in the April issue of Human Molecular Genetics.


Giant imaging study identifies genes that govern brain size

by  /  19 April 2012

The largest brain imaging study ever performed has identified candidate genes that influence brain size and general intelligence, according to research published 15 April in Nature Genetics.


Genetics: Rare, common autism variants may function together

by  /  3 April 2012

Researchers have mapped networks of genes expressed at the same time and place in the brain and shown that rare and common autism-linked mutations are likely to function in the same pathways. The results were published 8 March in PLoS Genetics.

March 2012

Molecular mechanisms: Extra MeCP2 affects brain signaling

by  /  30 March 2012

Mice with an extra copy of MeCP2, the Rett syndrome gene, have impaired signaling between neurons in the hippocampus, a brain region that plays an important role in memory, according to a study published 29 February in The Journal of Neuroscience.

January 2012

Cognition and behavior: Brain scans yield few signs of autism

by  /  31 January 2012

The results of two new studies support recommendations against the use of brain scans to diagnose autism.

December 2011

Clinical research: Cancer drug could treat Angelman syndrome

by  /  21 December 2011

A cancer drug shows promise as a treatment for Angelman syndrome, according to a study published today in Nature.

November 2011

Molecular mechanisms: SHANK2 mutants alter synapses

by  /  30 November 2011

Three mutations in SHANK2, an autism-associated gene, each lead to abnormal synapses, the junctions between neurons, according to a study in Human Molecular Genetics.