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Spectrum: Autism Research News

Tag: mouse models

November 2019

Mouse study reveals overlooked target for autism therapies

by  /  20 November 2019

Blocking one form of an enzyme implicated in autism eases unusual behaviors and seizures in mice missing a top autism gene.

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Micrograph of mouse brain showing transplanted human microglia

Chimeric mouse model aids study of brain’s immune cells

by  /  15 November 2019

A new technique allows researchers to transplant human microglia into mouse brains and better study the association between these cells and autism.

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October 2019
micrographs of brain areas in red.

Drug counteracts effects of doubled autism gene

by  /  24 October 2019

An experimental drug tamps down the expression of a gene duplicated in an autism-related condition and restores typical behavior in mice.

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Two pairs of neurons shown in red.

Gene editing rids mice of DNA segment linked to autism

by  /  23 October 2019

Researchers have used a new gene-editing technique to delete a segment of DNA associated with autism and schizophrenia from mouse brain cells.

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white mouse

Double immune hit challenges female mice’s resistance to autism

by  /  23 October 2019

Female mice can withstand a maternal antibody that triggers brain abnormalities and autism-like behaviors in males. But additional immune challenges spell trouble.

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Researchers debut mouse model for new autism gene

by  /  23 October 2019

Mice lacking one copy of a gene called DDX3X have developmental delay and sensory, motor and behavioral problems — similar to those seen in people with a mutation in the gene.

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Cesarean sections may leave young brains vulnerable to injury

by  /  22 October 2019

Delivery by cesarean section leads to subtle brain and behavioral alterations in mice, particularly those delivered prematurely.

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two neurons on yellow and orange background

Brain’s sensory relay station may play unexpected role in autism

by  /  22 October 2019

Neurons in a brain region called the thalamus may regulate social behavior and play a key role in autism.

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linked hands in a pattern intertwined with DNA showing some broken parts, symbolizing mutations

Rett syndrome’s link to autism, explained

by  /  21 October 2019

Studies of Rett syndrome hint at genes, cells and brain circuits that may be involved in autism — and may pave the way to treatments for both conditions.

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A new technique helps reveal patterns in the migration of neurons (green) to their destination (red).

A stop-motion movie of the whole brain, starring new neurons

by  /  21 October 2019

A method that visualizes nascent and migrating neurons in the mouse brain may shed light on brain development in autistic people.

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