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Spectrum: Autism Research News

Tag: mouse models

June 2020

New atlas maps mouse brain in 3D

by  /  17 June 2020

A new high-resolution atlas provides the most detailed views of mouse brain structure to date.

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May 2020

Extra proteins alter microglia and behavior in mice

by  /  29 May 2020

The overproduction of proteins in brain cells called microglia causes social impairments, cognitive deficits and repetitive behavior in male mice, a new study has found.

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Reversing SHANK3 mutations in mice mitigates autism-like traits

by  /  28 May 2020

Correcting an autism gene mutation in fetal mice lessens some autism-like behaviors after birth.

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Ultra-sensitive protein activates neurons in response to external light

by  /  27 May 2020

A new, minimally invasive technique allows researchers to activate neurons in the brains of mice and monkeys by using a light source located outside of the head.

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April 2020
Two neuron images compared side by side

Lithium may treat behavior linked to autism gene

by  /  24 April 2020

The mood-stabilizing drug lithium seems to ease repetitive behaviors seen in mice missing SHANK3, an autism gene.

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White mouse grooming

Gene linked to schizophrenia tied to autism-like behaviors

by  /  23 April 2020

Mice missing DLG2, a protein central to neuronal activity, are anxious, sleep poorly and overgroom themselves.

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New atlas maps gene expression throughout the brain

by  /  22 April 2020

A comprehensive atlas of gene expression by brain region could spur new research on autism.

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March 2020
Close-up of mouse face and whiskers.

Sensory sensitivity in autistic people may stem from subset of neurons

by  /  27 March 2020

Mice missing an autism gene called SHANK3 tend to be hypersensitive to touch, which may stem from underactivity of neurons that normally dampen sensory responses.

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Color-coded mouse brain scans

Machine designed for mouse brain imaging may help autism studies

by  /  6 March 2020

A custom-built machine can scan the brains of awake mice and may improve our understanding of conditions such as autism.

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Coloured transmission electron micrograph (TEM) showing several unmyelinated (green) and myelinated (green with blue border) axons. Schwann cell cytoplasm is red and a nucleus (bottom left) is yellow. The pink lines are the basement membranes.

Loss of insulation on neurons may contribute to autism

by  /  6 March 2020

Genes involved in the formation of myelin, a fatty substance that sheathes neurons, are altered in autistic people and in several mouse models.

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