How microscopic ‘condensates’ in cells might contribute to autism
A controversial idea about how cells compartmentalize their contents into droplets — like beads of oil in water — could be key to understanding autism, says Julie Forman-Kay.
A controversial idea about how cells compartmentalize their contents into droplets — like beads of oil in water — could be key to understanding autism, says Julie Forman-Kay.
Misaligned gene expression maps suggest that some autism-linked genes play distinct roles in mouse and human brains.
Merging 3D clusters of neurons that mimic different brain regions models the atypical electrical activity seen in an autism-related condition.
Mutations in a top autism gene called SYNGAP1 slow the rate at which zebrafish digest food and pass waste, and may also disrupt gut function in people.
Like so many other events this year, autism’s biggest annual conference — the International Society for Autism Research meeting — was forced to go virtual because of the coronavirus pandemic.
The autism gene SHANK3 is crucial for the development and function of muscles and the motor neurons that control them.
Correcting an autism gene mutation in fetal mice lessens some autism-like behaviors after birth.
The mood-stabilizing drug lithium seems to ease repetitive behaviors seen in mice missing SHANK3, an autism gene.
Mice missing an autism gene called SHANK3 tend to be hypersensitive to touch, which may stem from underactivity of neurons that normally dampen sensory responses.
Lowering the levels of a protein called tau, best known for its involvement in Alzheimer’s disease, improves behavior in two mouse models of autism.