Working with mice? Question their background
A standard mouse strain used by researchers worldwide harbors an unintended mutation that impairs immune cell development — and may confound results.
A standard mouse strain used by researchers worldwide harbors an unintended mutation that impairs immune cell development — and may confound results.
A newly created strain of mice lacking SHANK3 closely mimics the effects of the protein’s loss in some people with autism.
The anxiety and trouble with social skills seen in people with autism may originate outside of the brain, in neurons that govern touch.
The autism-linked gene SHANK3 is known for its role at neuronal junctions, but it has another function that could serve as a drug target.
A widely used technique for identifying subtypes of neurons in the brain may be flawed, and may have provided incorrect tallies of a key neuron type in autism.
Taking a close look at people who have a mutation in a known autism gene may reveal why these people often have vastly different characteristics.
Treatments for autism might be effective even after the brain is fully formed.
Growing neurons on tiny plates studded with miniature electrodes allows researchers to map patterns of neuronal activity within circuits.
Two seemingly similar mutations in the SHANK3 gene have divergent effects on the brain and behavior.
The same autism-linked mutation can lead to dramatically different behaviors in rats and mice.