Tag: SHANK3

June 2019
fMRIs of monkey brains in a grid of 6 show highlighted areas.
News

Monkeys with autism mutation show condition’s key traits

by  /  12 June 2019

Researchers have engineered two generations of monkeys with mutations in SHANK3, a top autism gene. The first generation shows traits reminiscent of the condition.

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May 2019
Young girl sleeping in the bed
News

Sleep struggles in autistic people may have genetic basis

by  /  3 May 2019

Autistic children may be more likely than their unaffected siblings to carry mutations in genes linked to sleep.

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February 2019
News

Drugs that modify gene expression show promise for autism

by  /  28 February 2019

An experimental compound that blocks two enzymes involved in gene expression improves social behavior in young mice.

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News

Brain’s prefrontal cortex conducts symphony of social players

by  /  20 February 2019

A brain region that orchestrates responses to social cues and aids decision-making may be off tempo in autism.

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Gabin and his father at home in Paris.
Features / Deep Dive

Europe’s race to ramp up genetic tests for autism

by  /  13 February 2019

Many countries in Europe are reckoning with the growing demand for genetic tests for autistic people — and the accompanying ethical and scientific considerations.

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January 2019
illustration shows woman under umbrella, with genes falling like rain
Opinion / Viewpoint

Expliquer la résilience à l’autisme peut faire naître de nouvelles thérapies

by  /  18 January 2019

Researchers have engineered two generations of monkeys with mutations in SHANK3, a top autism gene. The first generation shows traits reminiscent of the condition, according to a study published today in Nature1. The researchers are the first to engineer monkeys using the gene-editing tool CRISPR and then to breed a second generation using sperm from […]

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December 2018
whimsical machine takes in various data and spits out an organized version on the other end
Features / Special Reports / 2018: Year in Review

Notable papers in autism research in 2018

21 December 2018

This year’s list of top papers highlights new dimensions in our understanding of autism genetics and hints at novel treatments.

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November 2018
Monkey looks to the left.
News

Monkey with mutation in top autism gene shows social problems

by  /  14 November 2018

The first monkey with a mutation in SHANK3, a top autism gene, is nearly 3; it spends its days circling its cage rather than interacting with other monkeys.

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white mouse in a man's hands, closeup.
News

Mouse, human ‘co-clinical’ trials could speed autism drug discovery

by  /  8 November 2018

A team of researchers is trialing a fast approach to autism drug development: simultaneously testing candidates in people and in mice.

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News

Pattern of squeaks corresponds to social behavior in autism mice

by  /  5 November 2018

The pattern of high-pitched calls a mouse makes may reflect how, and how much, it is interacting with other mice. The pattern holds for typical mice as well as for two mouse models of autism.

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