Tag: SHANK3

January 2019
illustration shows woman under umbrella, with genes falling like rain
Opinion / Viewpoint

Expliquer la résilience à l’autisme peut faire naître de nouvelles thérapies

by  /  18 January 2019

This article is also available in anglais. Il y a quelques années la mère d’un jeune autiste m’a téléphoné. Elle venait d’apprendre que son fils, qui était dans la vingtaine, avait une délétion de SHANK3, l’un des gènes qui, d’après les découvertes de mon équipe, subit une mutation chez certaines personnes autistes. Cette nouvelle m’a […]

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December 2018
whimsical machine takes in various data and spits out an organized version on the other end
Features / Special Reports / 2018: Year in Review

Notable papers in autism research in 2018

21 December 2018

This year’s list of top papers highlights new dimensions in our understanding of autism genetics and hints at novel treatments.

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November 2018
Monkey looks to the left.
News

Monkey with mutation in top autism gene shows social problems

by  /  14 November 2018

The first monkey with a mutation in SHANK3, a top autism gene, is nearly 3; it spends its days circling its cage rather than interacting with other monkeys.

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white mouse in a man's hands, closeup.
News

Mouse, human ‘co-clinical’ trials could speed autism drug discovery

by  /  8 November 2018

A team of researchers is trialing a fast approach to autism drug development: simultaneously testing candidates in people and in mice.

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News

Pattern of squeaks corresponds to social behavior in autism mice

by  /  5 November 2018

The pattern of high-pitched calls a mouse makes may reflect how, and how much, it is interacting with other mice. The pattern holds for typical mice as well as for two mouse models of autism.

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October 2018
Illustration of human brain in brackets suggesting circuit alterations that is associated with certain genetic mutations.
Opinion / Viewpoint

Brain scans of sleeping mice hint at subtypes of autism

by  /  9 October 2018

Mapping the effects of autism mutations on mouse brain circuits may reveal subtypes of the condition in people.

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June 2018
News

Mutations in autism gene may trigger milder effects than does its loss

by  /  20 June 2018

People with mutations in SHANK3 have milder features than do those missing a chunk of DNA that includes the gene.

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Week of JuneJun
11th
2018
News / Spotted

Drug dangers; allergy risk; science #MeToo and more

by  /  15 June 2018

A prospective study shows that antipsychotics mess up metabolism, autism is tied to a doubled risk for food allergies, and a report reveals pervasive sexual harassment in science.

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May 2018
Multimedia / Webinars

Journal club: Rescue of social deficits in autism mouse model

23 May 2018

Watch the complete replay of this journal club, which featured a paper describing the rescue of social deficits in a SHANK3 mouse model.

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April 2018
four scientists standing on colorful tile
News

CRISPR goes wild, and scientists debate its fidelity

by  /  30 April 2018

The gene-editing tool CRISPR may cause thousands of off-target mutations, but critics say it’s way too soon to accuse it of infidelity.

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