Skip to main content

Tag: SHANK3

September 2021
researcher holds zebrafinch
Features

Fish, frogs, flies and other fauna in scientific firsts

by  /  8 September 2021

Over the past century, scientists have used a variety of animal models to advance their understanding of the developing brain and autism.

0 Comments
A lighthearted, colorful, chaotic lab scene with fruit flies, worms peeking out of petri dishes, zebrafish in beakers and an octopus creeping out of a cabinet..
Features / Special Reports

Special report: Unusual animal models of autism

8 September 2021

In the past two decades, some autism researchers have turned to simple animals, such as roundworms, fruit flies and zebrafish, for their investigations. Others have sought answers from experiments with frogs, birds and even octopuses.

0 Comments
A lighthearted, colorful, chaotic lab scene with fruit flies flying in formation, worms peeking out of piles of dirt and zebrafish spilling out of beakers.
Features / Deep Dive

What studying worms, flies and fish says about autism

by  /  8 September 2021

Researchers are increasingly turning to simple animals to learn about autism biology and find leads for new drugs.

0 Comments
August 2021
Close-up profile of child with focus on eye.
News

Visual response shows promise as biomarker in autism-linked condition

by  /  23 August 2021

Brain responses to visual stimuli are smaller and weaker in children with Phelan-McDermid syndrome, an autism-linked genetic condition, than in non-autistic children.

0 Comments
July 2021
Four brown lab mice in a cage, top-down view, with one mouse away from the group.
News

Autism-linked mutation may blur brain’s boundary between self, others

by  /  15 July 2021

A mutation in the autism-linked gene SHANK3 changes how neurons encode information about social agency in mice.

0 Comments
June 2021
Mouse neuron recordings showing different levels of activity before and after an encounter with an unfamiliar mouse.
News

Neural network captures noisy neurons in autism mouse model

by  /  18 June 2021

Mice missing the autism-linked gene SHANK3 use more neurons to engage in social behavior than control mice do, reflecting a more disorganized, less efficient brain signaling network.

0 Comments
April 2021
Macaques on dead trees on Cayo Santiago.
Opinion / Q&A

Friends of friends: How monkey island’s residents bonded after Hurricane Maria

by  /  13 April 2021

On 20 September 2017, Hurricane Maria passed over Puerto Rico’s Cayo Santiago Island, home to more than 1,500 non-native rhesus macaques. After the storm, the monkeys formed new, unexpected relationships in ways that could offer clues about autism.

0 Comments
March 2021
A digital rendering of a green neuron on black
News

Brain activity jump-starts autism-linked genes in human neurons

by  /  5 March 2021

Some neurons activate autism-linked genes when they fire, according to a new study.

0 Comments
February 2021
Oil and water with colors behind: blue, green, yellow and red.
Opinion / Q&A

How microscopic ‘condensates’ in cells might contribute to autism

by  /  23 February 2021

A controversial idea about how cells compartmentalize their contents into droplets — like beads of oil in water — could be key to understanding autism, says Julie Forman-Kay.

0 Comments
Oligodendrocyte gene grouping showing network of blue lines connecting the gene names on reddish bubbles.
News

Differing gene functions across species may pose problems for autism models

by  /  22 February 2021

Misaligned gene expression maps suggest that some autism-linked genes play distinct roles in mouse and human brains.

0 Comments