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Spectrum: Autism Research News

Tag: SHANK3

July 2022

New software flags autism rat model’s telltale squeaks

by  /  29 July 2022

By breaking rodent vocalizations into parts, TrackUSF distinguishes rats with mutations in the SHANK3 gene from their wildtype counterparts.

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June 2022
A computer-rendered analysis of neurons

Autism-linked mutation disrupts brain circuit to change social behavior

by  /  24 June 2022

Therapies that target the circuit could boost social activity, new findings suggest.

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Poor sleep shifts social circuit in mice

by  /  20 June 2022

Even temporary bouts of too little non-REM sleep can lead to long-term changes in how the animals respond to certain social situations, new research suggests.

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Two top autism-linked proteins connect to build cell ‘skeleton’

by  /  9 June 2022

ADNP and SHANK3 proteins may bind together and alter a neuron’s internal scaffold, hinting at a mechanism that, when disrupted, may underlie several forms of autism.

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May 2022
Ultrasound in black and white shows a pattern.

Heart anomalies abound in mouse models of autism

by  /  23 May 2022

Of nine genetic models examined in a new study, all had some incidence of cardiac abnormalities. But the problems varied widely depending on the affected genes.

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Lab mice (Mus musculus), tribe Balbc, three 13 day old babies with eyes still closed, laying side by side

Sleepy mice with autism-linked mutation struggle to fall asleep

by  /  19 May 2022

Mice with a mutated copy of SHANK3 fail to establish normal sleep patterns during development.

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Scientist Lucia Peixoto portrait.

Rising star: Lucia Peixoto, breaking down the interplay between sleep and autism

by  /  9 May 2022

The young researcher from Uruguay uses her expertise in genetics — and discipline as a former athlete — to untangle sleep’s role in neurodevelopmental conditions, one experiment at a time.

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April 2022

Histone-modifying drug improves autism-like behaviors in mice

by  /  18 April 2022

The experimental compound, called GSK-LSD1, enhances social preferences and reduces repetitive grooming in mice, according to a new study.

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March 2022

Unfamiliar surroundings bring out autism-like behaviors, brain circuit changes in model mice

by  /  31 March 2022

A brain area called the tail of the striatum may account for the shift.

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A family of Macaques aat the Yerkes National Primate Research Center Field Station, Lawrenceville, Georgia.

Macaques’ social skills tied to variation in autism-linked genes

by  /  7 March 2022

Genetics strongly influences some aspects of the monkey’s social behavior, including tendencies to solicit grooming and sit or play alone.

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