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Tag: Rett syndrome

February 2012
News

Clinical research: Two compounds treat Rett syndrome in mice

by  /  1 February 2012

Two compounds that enhance the activity of BDNF, a protein needed for the growth of neurons, improve motor skills in mouse models of Rett syndrome and increase the mice’s lifespan.

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January 2012
News / Toolbox

New resource compiles data on autism-linked genes

by  /  18 January 2012

A new online database provides searchable information for nearly 10,000 genes, variants and chromosomal regions linked to autism. Researchers describe the resource, dubbed AutismKB, in the January issue of Nucleic Acids Research.

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News / Toolbox

Brain atlas maps gene expression across development

by  /  4 January 2012

Researchers have charted the expression of more than 15,000 brain genes across 15 stages of development, spanning from 4 weeks post-conception to more than 60 years of age, they reported 27 October in Nature.

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News

Cognition and behavior: Mouse models human Rett mutation

by  /  3 January 2012

A mouse model of Rett syndrome that mimics a mutation seen in people shows many features of the disorder, such as hand clasping, according to a study published 27 November in Nature Neuroscience.

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December 2011
News

Molecular mechanisms: Protein linked to autism-like behavior

by  /  9 December 2011

HMGN1, a protein that regulates gene expression, leads to social deficits and hyperactivity when expressed at elevated levels in mice, according to a study published 9 December in the Journal of Biological Chemistry. This effect may result from HMGN1 dampening MeCP2 expression, the study suggests.

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Opinion

Beyond stigma

by  /  2 December 2011

In China, some parents of children with developmental disorders seek help — sometimes hundreds of miles from home — but have trouble getting it because of poor healthcare infrastructure, high costs, long lines and doctors’ lack of awareness.

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November 2011
News / Toolbox

Stem cell lines shed light on autism-related disorders

by  /  23 November 2011

Researchers have derived neurons from stem cells to investigate mutations that lead to Rett and fragile X syndromes.

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Opinion / Viewpoint

A case for the importance of interneurons in autism

by ,  /  22 November 2011

The etiology of autism may be best understood as an impairment of neuronal circuits, specifically interneurons that dampen signals in the brain, says neuroscientist Gordon Fishell.  

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News

Rett, autism mouse brains mimic human disorders

by  /  17 November 2011

The brains of mice that model Rett syndrome are smaller than normal overall and have differences in specific regions similar to those seen in people with the disorder, according to unpublished research presented Wednesday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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News

Researchers map microRNAs in autism brains

by  /  17 November 2011

Researchers have charted the expression of tiny pieces of RNA in postmortem brain tissue from people with autism, according to unpublished research presented Tuesday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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