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Tag: Rett syndrome

April 2011
News

Molecular mechanisms: Mice lacking MET have strong brain connections

by  /  26 April 2011

Mice missing the autism candidate gene MET have connections in the cortex that are twice as strong as those in controls, according to a new study.

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News / Toolbox

Researchers make neurons from people with schizophrenia

by  /  20 April 2011

Researchers have taken skin cells from individuals with schizophrenia, bathed them in chemical cocktails and coaxed them to develop into neurons, according to a paper published 13 April in Nature.

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News

Maternal stress alters behavior of generations

by  /  18 April 2011

Early trauma alters both behavior and gene expression in three generations of mice, suggesting that epigenetic changes may contribute to ‘hidden heritability’ in neuropsychiatric disorders.

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January 2011
News

Genetics: Rare mutation found in gene linked to autism

by  /  31 January 2011

Researchers have identified a rare genetic variant linked to autism in DLX1, a gene that regulates the growth of neurons, they reported in December in the American Journal of Medical Genetics.

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December 2010
News

Jumping genes implicated in Rett syndrome

by  /  27 December 2010

The neurons of people with Rett syndrome contain an overabundance of retrotransposons — DNA sequences that copy and insert themselves into new spots throughout the genome — during early development, according to a study published 18 November in Nature.

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News

Scientists capture microglia’s role in brain connectivity

by  /  20 December 2010

Scientists are changing their minds about the role of microglia, the brain’s strongest and most agile soldiers against damage and infection. In healthy brains, microglia help build and eliminate synapses, the junctions between neurons, according to a study published 2 November in PLoS Biology.

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News

Calming neurons may ease apnea in Rett syndrome

by  /  9 December 2010

A controversial new approach that quiets the activity of certain neurons in the brain alleviates breathing difficulties in a mouse model of Rett syndrome, according to a study published 4 October in the Proceedings of the National Academy of Sciences.

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November 2010
News

Video: Synapses are key to understanding autism

by  /  18 November 2010

Proteins that function at the synapse, the junction between neurons, have been strongly linked to autism. At the Society for Neuroscience annual meeting in San Diego, Mriganka Sur, professor of neuroscience at the Massachusetts institute of technology, explained how studying synapses is revolutionizing our understanding of autism.

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News

Video: Inhibitory neurons involved in Rett syndrome

by  /  17 November 2010

In a study published last week, Huda Zoghbi’s team showed that neurons that produce a neurotransmitter called gamma-aminobutyric acid, or GABA, play a crucial role in the development of Rett syndrome. Zoghbi caught up with SFARI at the Society for Neuroscience annual meeting in San Diego to discuss the study’s implications for understanding autism.

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News

Stem cell assay reveals early development of Rett neurons

by  /  16 November 2010

Researchers have developed the first stem cell system that makes it possible to study the early development of neurons from people with Rett syndrome, a rare disorder on the autism spectrum.

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